ZNRD1

Entrez Summary: N/A
UniProt Summary: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 351/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	13/28
blood	5/28
bone	6/25
breast	18/33
central nervous system	34/56
cervix	2/4
colorectal	7/17
esophagus	9/13
fibroblast	1/1
gastric	5/15
kidney	15/21
liver	9/20
lung	34/75
lymphocyte	7/14
ovary	13/26
pancreas	12/24
peripheral nervous system	6/16
plasma cell	2/15
prostate	0/1
skin	8/24
soft tissue	4/7
thyroid	1/2
upper aerodigestive	13/22
urinary tract	19/29
uterus	4/5

Expression Distribution

RNA polymerase I activity
RNA polymerase I complex
mRNA cleavage
transcription elongation from RNA polymerase I promoter
termination of RNA polymerase I transcription
DNA-directed 5-3 RNA polymerase activity
transcription initiation from RNA polymerase I promoter
transcription by RNA polymerase I
positive regulation of gene expression, epigenetic
DNA-templated transcription, termination
DNA-templated transcription, elongation
RNA phosphodiester bond hydrolysis
nucleic acid binding
DNA-templated transcription, initiation
regulation of gene expression, epigenetic
nucleic acid phosphodiester bond hydrolysis
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
mRNA metabolic process
zinc ion binding
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
positive regulation of gene expression
gene expression