ZNRF3

Gene Information

Official Symbol: ZNRF3
Official Name: zinc and ring finger 3
Aliases and Previous Symbols: N/A
Entrez ID: 84133
UniProt: Q9ULT6
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non- canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone. {ECO:0000269|PubMed:22575959}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 5775
Expression level (log2 read counts): 4.18

Expression Distribution

zf-rbx1
zf-C3HC4

Wnt receptor catabolic process
negative regulation of non-canonical Wnt signaling pathway
regulation of Wnt signaling pathway, planar cell polarity pathway
regulation of non-canonical Wnt signaling pathway
receptor catabolic process
frizzled binding
stem cell proliferation
receptor metabolic process
regulation of establishment of planar polarity
negative regulation of canonical Wnt signaling pathway
limb development
appendage development
regulation of morphogenesis of an epithelium
negative regulation of Wnt signaling pathway
ubiquitin protein ligase activity
ubiquitin-protein transferase activity
regulation of animal organ morphogenesis
regulation of canonical Wnt signaling pathway
Wnt signaling pathway
cell-cell signaling by wnt
regulation of Wnt signaling pathway
cell surface receptor signaling pathway involved in cell-cell signaling
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
cell population proliferation
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
protein catabolic process
protein ubiquitination
protein modification by small protein conjugation
cellular macromolecule catabolic process
protein modification by small protein conjugation or removal
macromolecule catabolic process
organonitrogen compound catabolic process
regulation of anatomical structure morphogenesis
cell-cell signaling
negative regulation of signal transduction
proteolysis
negative regulation of cell communication