ZSWIM2

Entrez Summary: N/A
UniProt Summary: E3 ubiquitin-protein ligase involved in the regulation of Fas-, DR3- and DR4-mediated apoptosis. Functions in conjunction with the UBE2D1, UBE2D3 and UBE2E1 E2 ubiquitin-conjugating enzymes. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of extrinsic apoptotic signaling pathway
regulation of extrinsic apoptotic signaling pathway via death domain receptors
protein self-association
regulation of extrinsic apoptotic signaling pathway
positive regulation of apoptotic signaling pathway
ubiquitin protein ligase activity
protein polyubiquitination
regulation of apoptotic signaling pathway
positive regulation of apoptotic process
positive regulation of programmed cell death
protein ubiquitination
positive regulation of cell death
protein modification by small protein conjugation
zinc ion binding
apoptotic process
protein modification by small protein conjugation or removal
programmed cell death
cell death
regulation of apoptotic process
regulation of programmed cell death
positive regulation of signal transduction
regulation of cell death
positive regulation of cell communication
positive regulation of signaling