5-Fluorouracil 2μM R00 exp1

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Thymidylate synthase inhibitor, blocks DNA replication

Class / Subclass 1: Metabolism / Antimetabolite
Class / Subclass 2: DNA Damage, Repair and Replication / Replication Inhibitor

Sensitive/Resistant hits (FDR<0.05)	CRANKS	Score Plot	Top 30 Genes	Screen Similarity	Top 30 Sensitive GO terms	Top 30 Resistant GO terms
2/3	Scores	View	View	View	View	View

GO Term	Fold Change	Genes
polyadenylation-dependent ncRNA catabolic process	169.19	ZCCHC7,TENT4B
sno(s)RNA metabolic process	78.96	ZCCHC7,TENT4B
guanyl-nucleotide exchange factor complex	78.96	RIC1,LAMTOR4
negative regulation of telomere maintenance via telomerase	62.33	TENT4B,TEN1
telomerase RNA binding	59.22	TENT4B,NAF1
acetylcholine-gated monoatomic cation-selective channel activity	53.83	CHRNB3,HTR3E
negative regulation of telomere maintenance via telomere lengthening	47.37	TENT4B,TEN1
regulation of telomere maintenance via telomere lengthening	30.11	TENT4B,NAF1,TEN1
mRNA catabolic process	19.26	YTHDF2,ZCCHC7,TENT4B,RNPS1
nuclear-transcribed mRNA catabolic process	17.77	ZCCHC7,TENT4B,RNPS1
regulation of telomere maintenance	17.42	TENT4B,NAF1,TEN1
regulation of DNA biosynthetic process	14.80	TENT4B,NAF1,TEN1
RNA catabolic process	14.53	YTHDF2,ZCCHC7,TENT4B,RNPS1
nucleobase-containing compound catabolic process	10.50	YTHDF2,ZCCHC7,TENT4B,UNG,RNPS1
cellular nitrogen compound catabolic process	9.05	YTHDF2,ZCCHC7,TENT4B,UNG,RNPS1
heterocycle catabolic process	9.00	YTHDF2,ZCCHC7,TENT4B,UNG,RNPS1
aromatic compound catabolic process	8.73	YTHDF2,ZCCHC7,TENT4B,UNG,RNPS1
organic cyclic compound catabolic process	7.94	YTHDF2,ZCCHC7,TENT4B,UNG,RNPS1
catalytic activity, acting on a nucleic acid	5.94	TENT4B,FTSJ1,MCM9,ALKBH8,DDX39A,UNG

GO Term	Fold Change	Genes
negative regulation of microtubule depolymerization	48.06	TPX2,CLASP1
microtubule plus-end	48.06	CLASP1,CKAP5
microtubule polymerization	41.45	TPX2,CLASP1,CKAP5
mitotic spindle assembly	36.05	KIF11,TPX2,CLASP1
microtubule polymerization or depolymerization	28.59	TPX2,CLASP1,CKAP5
mitotic spindle organization	24.03	KIF11,TPX2,CLASP1,CKAP5
regulation of microtubule polymerization or depolymerization	17.83	TPX2,CLASP1,CKAP5
microtubule cytoskeleton organization involved in mitosis	17.41	KIF11,TPX2,CLASP1,CKAP5
protein polymerization	16.75	TPX2,CLASP1,CKAP5
spindle assembly	15.64	KIF11,TPX2,CLASP1
microtubule organizing center organization	15.21	KIF11,CLASP1,CKAP5
spindle organization	13.00	KIF11,TPX2,CLASP1,CKAP5
chromosome organization	7.54	KIF11,TOP1MT,TPX2,CLASP1,SSBP1,TFIP11
negative regulation of cellular component organization	6.55	TPX2,HNRNPA1,MPHOSPH9,DNM2,CDKL3,CLASP1,TFIP11,SNX3
mitotic cell cycle process	6.44	KIF11,WEE1,TPX2,DNM2,CLASP1,CKAP5
mRNA processing	6.41	SUPT6H,HNRNPA1,ECD,PAF1,TFIP11
microtubule	6.37	KIF11,TPX2,DNM2,CLASP1,CKAP5
mitotic cell cycle	5.54	KIF11,WEE1,TPX2,DNM2,CLASP1,CKAP5
cell cycle process	4.44	KIF11,WEE1,TPX2,RPL23,DNM2,CLASP1,CKAP5

Screen	Correlation	Plot
DABN 2μM R00 exp16	0.068	View
Cycloheximide 0.2μM R00 exp15	0.059	View
Pimelic-diphenylamide-106 0.5μM R00 exp27	0.053	View