UM0011500 5μM R05 exp245 [The Human Chemical-Genetic Interaction Map Project]

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====== UM0011500 5μM R05 exp245 ======
==== Mechanism of Action ====
Unknown
  * **<color #00a2e8>Class / Subclass 1:</color>** Uncharacterized Mechanism / Chemical Screen Hit




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%3-(5,6-Dimethyl-1,3-dihydroisoindol-2-yl)-N-[(Z)-furan-2-ylmethylideneamino]benzamide%%
    * **<color #00a2e8>Synonyms:</color>** N/A
    * **<color #00a2e8>CAS #:</color>** 331431-73-3
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/5440778|5440778]]
    * **<color #00a2e8>IUPAC:</color>** %%3-(5,6-dimethyl-1,3-dihydroisoindol-2-yl)-N-[(Z)-furan-2-ylmethylideneamino]benzamide%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C22H21N3O2/c1-15-9-18-13-25(14-19(18)10-16(15)2)20-6-3-5-17(11-20)22(26)24-23-12-21-7-4-8-27-21/h3-12H,13-14H2,1-2H3,(H,24,26)/b23-12-
    * **<color #00a2e8>INCHI Key:</color>** GEVKZGPEQJGUIW-FMCGGJTJSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 359.42
    * **<color #00a2e8>Canonical SMILES:</color>** CC1=CC2=C(CN(C2)C3=CC=CC(=C3)C(=O)NN=CC4=CC=CO4)C=C1C
    * **<color #00a2e8>Isomeric SMILES:</color>** CC1=CC2=C(CN(C2)C3=CC=CC(=C3)C(=O)N/N=C\\C4=CC=CO4)C=C1C
    * **<color #00a2e8>Molecular Formula:</color>** C22H21N3O2
{{:chemogenomics:structures:chem-0150.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Chem Bridge
    * **<color #00a2e8>Catalog #:</color>** 5554888
    * **<color #00a2e8>Lot #:</color>** Batch #01
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** [M+H]+ Calcd for C22H22N3O2 360.1707; found 360.1618
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** UM0011500
    * **<color #00a2e8>Min:</color>** -8.2089; **<color #00a2e8>Max:</color>** 6.7698
{{:chemogenomics:dose_response:dr_246.png?nolink&500 |}}
\\ 
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|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |N/A    |
| IC30  |N/A    |
| IC40  |N/A    |
| IC50  |N/A    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 05
    * **<color #00a2e8>Dose</color>**: 5µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 6.6
    * **<color #00a2e8>Numbers of reads</color>**: 17275503


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|7/2|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/UM0011500_5uM_Round-5_exp245.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="default" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='UM0011500 5μM R05 exp245'>
{{:chemogenomics:cranks_plots:exp245.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:P:PPT1|PPT1]]|-3.82|<0.01|
|[[:human_genes:K:KDSR|KDSR]]|-3.57|<0.01|
|[[:human_genes:M:MEF2C|MEF2C]]|-3.29|<0.01|
|[[:human_genes:S:SSR2|SSR2]]|-3.02|<0.01|
|[[:human_genes:N:NPRL3|NPRL3]]|-3.00|0.02|
|[[:human_genes:C:CCDC22|CCDC22]]|-2.80|0.01|
|[[:human_genes:S:SLC5A3|SLC5A3]]|-2.67|0.02|
|[[:human_genes:A:ADSL|ADSL]]|-2.57|0.16|
|[[:human_genes:U:UGGT1|UGGT1]]|-2.55|0.08|
|[[:human_genes:S:STT3A|STT3A]]|-2.48|0.15|
|[[:human_genes:P:PLA2G15|PLA2G15]]|-2.46|0.09|
|[[:human_genes:P:PGGT1B|PGGT1B]]|-2.40|0.08|
|[[:human_genes:Z:ZRSR2|ZRSR2]]|-2.35|0.09|
|[[:human_genes:A:ATRX|ATRX]]|-2.33|0.09|
|[[:human_genes:R:RPP21|RPP21]]|-2.31|0.09|
|[[:human_genes:M:MCM9|MCM9]]|-2.28|0.15|
|[[:human_genes:R:RABGEF1|RABGEF1]]|-2.27|0.15|
|[[:human_genes:R:RPE|RPE]]|-2.27|0.15|
|[[:human_genes:L:LIPA|LIPA]]|-2.25|0.12|
|[[:human_genes:S:SEPHS1|SEPHS1]]|-2.17|0.18|
|[[:human_genes:S:SNX18|SNX18]]|-2.16|0.25|
|[[:human_genes:M:MBNL1|MBNL1]]|-2.15|0.15|
|[[:human_genes:Z:ZBTB7A|ZBTB7A]]|-2.15|0.15|
|[[:human_genes:A:AP5Z1|AP5Z1]]|-2.14|0.15|
|[[:human_genes:G:GYS2|GYS2]]|-2.11|0.16|
|[[:human_genes:G:GCLC|GCLC]]|-2.09|0.22|
|[[:human_genes:A:ASB3|ASB3]]|-2.09|0.17|
|[[:human_genes:U:UNC50|UNC50]]|-2.08|0.17|
|[[:human_genes:S:SCO2|SCO2]]|-2.08|0.17|
|[[:human_genes:P:PMM2|PMM2]]|-2.07|0.17|
|[[:human_genes:C:CD33|CD33]]|2.01|0.35|
|[[:human_genes:A:AURKA|AURKA]]|2.02|0.49|
|[[:human_genes:R:RPL10A|RPL10A]]|2.04|0.51|
|[[:human_genes:P:PSMC2|PSMC2]]|2.07|0.51|
|[[:human_genes:N:NKAP|NKAP]]|2.07|0.45|
|[[:human_genes:P:PDE7A|PDE7A]]|2.09|0.30|
|[[:human_genes:P:POLR2L|POLR2L]]|2.10|0.69|
|[[:human_genes:K:KIAA1671|KIAA1671]]|2.11|0.35|
|[[:human_genes:C:CHD4|CHD4]]|2.14|0.44|
|[[:human_genes:C:COPB2|COPB2]]|2.15|0.57|
|[[:human_genes:R:RRP7A|RRP7A]]|2.18|0.31|
|[[:human_genes:C:CCDC41|CCDC41]]|2.21|0.30|
|[[:human_genes:U:UBE2G1|UBE2G1]]|2.22|0.18|
|[[:human_genes:P:POLA1|POLA1]]|2.23|0.60|
|[[:human_genes:M:MGST1|MGST1]]|2.26|0.15|
|[[:human_genes:C:COPB1|COPB1]]|2.26|0.51|
|[[:human_genes:K:KRTAP4-9|KRTAP4-9]]|2.27|0.15|
|[[:human_genes:N:NPC2|NPC2]]|2.31|0.15|
|[[:human_genes:M:M6PR|M6PR]]|2.35|0.14|
|[[:human_genes:L:LLPH|LLPH]]|2.41|0.27|
|[[:human_genes:E:EIF4E1B|EIF4E1B]]|2.41|0.15|
|[[:human_genes:N:NGDN|NGDN]]|2.45|0.35|
|[[:human_genes:R:RPS19|RPS19]]|2.46|0.45|
|[[:human_genes:C:CD72|CD72]]|2.47|0.09|
|[[:human_genes:N:NPC1|NPC1]]|2.51|0.09|
|[[:human_genes:D:DTL|DTL]]|2.52|0.30|
|[[:human_genes:S:SEC23B|SEC23B]]|2.53|0.14|
|[[:human_genes:T:TP53I13|TP53I13]]|2.81|0.06|
|[[:human_genes:P:PLBD2|PLBD2]]|2.92|0.01|
|[[:human_genes:P:PSAP|PSAP]]|4.08|<0.01|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp246|UM0011500 10μM R05 exp246]]|0.097|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp453|B02 10μM R08 exp453]]|0.056|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|0.052|<button type="primary" size="small" modal="3">View</button>|
</modal>


<modal id="1" size="lg" title="UM0011500 10μM R05 exp246  vs  UM0011500 5μM R05 exp245">
{{:chemogenomics:comparison_plots:exp245_vs_exp246.png?nolink |}}
</modal>

<modal id="2" size="lg" title="B02 10μM R08 exp453  vs  UM0011500 5μM R05 exp245">
{{:chemogenomics:comparison_plots:exp245_vs_exp453.png?nolink |}}
</modal>

<modal id="3" size="lg" title="CCT251545 0.2μM R06 exp271  vs  UM0011500 5μM R05 exp245">
{{:chemogenomics:comparison_plots:exp245_vs_exp271.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">No GO term hits below threshold. (FDR <0.05)</modal>