Hydroxyurea 100μM R07 exp329 [The Human Chemical-Genetic Interaction Map Project]

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====== Hydroxyurea 100μM R07 exp329 ======
==== Mechanism of Action ====
Inhibits ribonucleotide reductase, scavenges tyrosyl radicals
  * **<color #00a2e8>Class / Subclass 1:</color>** Metabolism / Metabolic Enzyme Inhibitor
  * **<color #00a2e8>Class / Subclass 2:</color>** DNA Damage, Repair and Replication / Replication Inhibitor



==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%Hydroxyurea%%
    * **<color #00a2e8>Synonyms:</color>** Hydroxycarbamide
    * **<color #00a2e8>CAS #:</color>** 127-07-1
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/3657|3657]]
    * **<color #00a2e8>IUPAC:</color>** %%hydroxyurea%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/CH4N2O2/c2-1(4)3-5/h5H,(H3,2,3,4)
    * **<color #00a2e8>INCHI Key:</color>** VSNHCAURESNICA-UHFFFAOYSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 76.055
    * **<color #00a2e8>Canonical SMILES:</color>** C(=O)(N)NO
    * **<color #00a2e8>Isomeric SMILES:</color>** N/A
    * **<color #00a2e8>Molecular Formula:</color>** CH4N2O2
{{:chemogenomics:structures:chem-0177.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Sigma-Aldrich
    * **<color #00a2e8>Catalog #:</color>** H8627
    * **<color #00a2e8>Lot #:</color>** MKBK3764V
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for CH4N2O2 77.03455; found 77.03325
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** Hydroxyurea
    * **<color #00a2e8>Min:</color>** -9.2854; **<color #00a2e8>Max:</color>** 77.4839
{{:chemogenomics:dose_response:dr_432.png?nolink&500 |}}
\\ 
\\ 
\\ 
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|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |0.0627    |
| IC30  |0.0980    |
| IC40  |0.1503    |
| IC50  |0.2373    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 07
    * **<color #00a2e8>Dose</color>**: 100µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 3.2
    * **<color #00a2e8>Numbers of reads</color>**: 16504567


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|24/95|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Hydroxyurea_100uM_Round-7_exp329.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="primary" size="sm" modal="modal_go_sensitive">View</button>|<button type="primary" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='Hydroxyurea 100μM R07 exp329'>
{{:chemogenomics:cranks_plots:exp329.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:R:RBM26|RBM26]]|-4.36|<0.01|
|[[:human_genes:G:GTPBP2|GTPBP2]]|-3.78|<0.01|
|[[:human_genes:C:CFLAR|CFLAR]]|-3.66|<0.01|
|[[:human_genes:K:KPNA4|KPNA4]]|-3.45|<0.01|
|[[:human_genes:M:MSI2|MSI2]]|-3.30|<0.01|
|[[:human_genes:C:CCDC111|CCDC111]]|-3.26|<0.01|
|[[:human_genes:R:RRM2|RRM2]]|-3.20|0.07|
|[[:human_genes:S:SPR|SPR]]|-3.14|<0.01|
|[[:human_genes:V:VPS25|VPS25]]|-3.03|0.05|
|[[:human_genes:Z:ZBTB10|ZBTB10]]|-3.01|<0.01|
|[[:human_genes:N:NPRL2|NPRL2]]|-2.95|<0.01|
|[[:human_genes:A:ATP6V0A2|ATP6V0A2]]|-2.87|0.01|
|[[:human_genes:R:RECQL5|RECQL5]]|-2.83|0.05|
|[[:human_genes:T:TRAF2|TRAF2]]|-2.76|0.02|
|[[:human_genes:W:WDR26|WDR26]]|-2.63|0.05|
|[[:human_genes:I:IREB2|IREB2]]|-2.60|0.02|
|[[:human_genes:K:KAT7|KAT7]]|-2.58|0.02|
|[[:human_genes:P:PDS5B|PDS5B]]|-2.56|0.02|
|[[:human_genes:U:UBE3D|UBE3D]]|-2.54|0.02|
|[[:human_genes:N:NPRL3|NPRL3]]|-2.54|0.06|
|[[:human_genes:P:PPIL1|PPIL1]]|-2.43|0.04|
|[[:human_genes:P:PLEKHG4B|PLEKHG4B]]|-2.41|0.04|
|[[:human_genes:S:SSU72|SSU72]]|-2.38|0.04|
|[[:human_genes:R:RIF1|RIF1]]|-2.37|0.06|
|[[:human_genes:W:WDR33|WDR33]]|-2.35|0.17|
|[[:human_genes:N:NDNL2|NDNL2]]|-2.35|0.10|
|[[:human_genes:W:WEE1|WEE1]]|-2.34|0.17|
|[[:human_genes:Z:ZBTB7A|ZBTB7A]]|-2.33|0.05|
|[[:human_genes:T:TOP1|TOP1]]|-2.32|0.05|
|[[:human_genes:X:XPR1|XPR1]]|-2.32|0.05|
|[[:human_genes:M:MRPS35|MRPS35]]|2.57|0.03|
|[[:human_genes:M:MRPL17|MRPL17]]|2.59|0.04|
|[[:human_genes:M:MRPS22|MRPS22]]|2.62|<0.01|
|[[:human_genes:G:GFM2|GFM2]]|2.62|<0.01|
|[[:human_genes:M:MRPL21|MRPL21]]|2.63|<0.01|
|[[:human_genes:S:SUPV3L1|SUPV3L1]]|2.63|0.01|
|[[:human_genes:D:DARS2|DARS2]]|2.63|0.02|
|[[:human_genes:M:MTPAP|MTPAP]]|2.64|<0.01|
|[[:human_genes:M:MRPS18A|MRPS18A]]|2.64|0.01|
|[[:human_genes:N:NDUFB11|NDUFB11]]|2.69|0.01|
|[[:human_genes:K:KLF16|KLF16]]|2.72|0.02|
|[[:human_genes:F:FASTKD5|FASTKD5]]|2.78|0.01|
|[[:human_genes:M:MRPL43|MRPL43]]|2.82|<0.01|
|[[:human_genes:N:NDUFA2|NDUFA2]]|2.82|<0.01|
|[[:human_genes:F:FTSJ2|FTSJ2]]|2.83|<0.01|
|[[:human_genes:Y:YARS2|YARS2]]|2.83|<0.01|
|[[:human_genes:U:UQCRC1|UQCRC1]]|2.83|<0.01|
|[[:human_genes:M:MBTPS2|MBTPS2]]|2.87|<0.01|
|[[:human_genes:M:MRPS2|MRPS2]]|2.89|<0.01|
|[[:human_genes:M:MRPS21|MRPS21]]|2.91|0.01|
|[[:human_genes:C:COX7B|COX7B]]|2.98|<0.01|
|[[:human_genes:H:HSD17B10|HSD17B10]]|2.99|<0.01|
|[[:human_genes:A:AASDHPPT|AASDHPPT]]|3.01|<0.01|
|[[:human_genes:E:EPC2|EPC2]]|3.02|<0.01|
|[[:human_genes:E:EIF4A1|EIF4A1]]|3.04|<0.01|
|[[:human_genes:S:SLFN11|SLFN11]]|3.08|<0.01|
|[[:human_genes:S:SCAP|SCAP]]|3.24|<0.01|
|[[:human_genes:F:FADS2|FADS2]]|3.25|<0.01|
|[[:human_genes:M:MRPL53|MRPL53]]|3.26|<0.01|
|[[:human_genes:M:MRPL23|MRPL23]]|3.34|<0.01|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|0.171|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|0.14|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|0.13|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|0.109|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|0.09|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|0.083|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp532|TIC10 10μM R08 exp532]]|0.078|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|0.077|<button type="primary" size="small" modal="8">View</button>|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|0.076|<button type="primary" size="small" modal="9">View</button>|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|0.076|<button type="primary" size="small" modal="10">View</button>|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|0.073|<button type="primary" size="small" modal="11">View</button>|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|0.061|<button type="primary" size="small" modal="12">View</button>|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|0.058|<button type="primary" size="small" modal="13">View</button>|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|0.057|<button type="primary" size="small" modal="14">View</button>|
|[[:results:exp59|UMK57 1μM R01 exp59]]|0.055|<button type="primary" size="small" modal="15">View</button>|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|0.053|<button type="primary" size="small" modal="16">View</button>|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|0.053|<button type="primary" size="small" modal="17">View</button>|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|0.052|<button type="primary" size="small" modal="18">View</button>|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|0.052|<button type="primary" size="small" modal="19">View</button>|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|0.051|<button type="primary" size="small" modal="20">View</button>|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|0.134|<button type="primary" size="small" modal="21">View</button>|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|0.127|<button type="primary" size="small" modal="22">View</button>|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|0.111|<button type="primary" size="small" modal="23">View</button>|
|[[:results:exp360|Genistein 15μM R07 exp360]]|0.103|<button type="primary" size="small" modal="24">View</button>|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|0.089|<button type="primary" size="small" modal="25">View</button>|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|0.08|<button type="primary" size="small" modal="26">View</button>|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|0.079|<button type="primary" size="small" modal="27">View</button>|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|0.076|<button type="primary" size="small" modal="28">View</button>|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|0.075|<button type="primary" size="small" modal="29">View</button>|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|0.074|<button type="primary" size="small" modal="30">View</button>|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|0.073|<button type="primary" size="small" modal="31">View</button>|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|0.065|<button type="primary" size="small" modal="32">View</button>|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|0.062|<button type="primary" size="small" modal="33">View</button>|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|0.06|<button type="primary" size="small" modal="34">View</button>|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|0.06|<button type="primary" size="small" modal="35">View</button>|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|0.059|<button type="primary" size="small" modal="36">View</button>|
|[[:results:exp211|AICAR 240μM R05 exp211]]|0.057|<button type="primary" size="small" modal="37">View</button>|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|0.056|<button type="primary" size="small" modal="38">View</button>|
|[[:results:exp539|42°C R08 exp539]]|0.052|<button type="primary" size="small" modal="39">View</button>|
</modal>


<modal id="1" size="lg" title="Hydroxyurea 100μM R07 exp329  vs  Thimerosal 0.85μM R08 exp529">
{{:chemogenomics:comparison_plots:exp329_vs_exp529.png?nolink |}}
</modal>

<modal id="2" size="lg" title="Hydroxyurea 100μM R07 exp329  vs  Pterostilbene 16μM R02 exp78">
{{:chemogenomics:comparison_plots:exp329_vs_exp78.png?nolink |}}
</modal>

<modal id="3" size="lg" title="Hydroxyurea 100μM R07 exp329  vs  UM0125461 0.74μM R02 exp84">
{{:chemogenomics:comparison_plots:exp329_vs_exp84.png?nolink |}}
</modal>

<modal id="4" size="lg" title="Hydroxyurea 100μM R07 exp329  vs  Oligomycin-A 2μM R00 exp25">
{{:chemogenomics:comparison_plots:exp25_vs_exp329.png?nolink |}}
</modal>

<modal id="5" size="lg" title="Hydroxyurea 100μM R07 exp329  vs  PU-H71 1μM R08 exp515">
{{:chemogenomics:comparison_plots:exp329_vs_exp515.png?nolink |}}
</modal>

<modal id="6" size="lg" title="Hydroxyurea 100μM R07 exp329  vs  Tanespimycin 14μM R08 exp527">
{{:chemogenomics:comparison_plots:exp329_vs_exp527.png?nolink |}}
</modal>

<modal id="7" size="lg" title="Hydroxyurea 100μM R07 exp329  vs  TIC10 10μM R08 exp532">
{{:chemogenomics:comparison_plots:exp329_vs_exp532.png?nolink |}}
</modal>

<modal id="8" size="lg" title="Hydroxyurea 100μM R07 exp329  vs  Tubacin 1.6μM R07 exp416">
{{:chemogenomics:comparison_plots:exp329_vs_exp416.png?nolink |}}
</modal>

<modal id="9" size="lg" title="Hydroxyurea 100μM R07 exp329  vs  Resveratrol 16μM R03 exp147">
{{:chemogenomics:comparison_plots:exp147_vs_exp329.png?nolink |}}
</modal>

<modal id="10" size="lg" title="Hydroxyurea 100μM R07 exp329  vs  ONC212 0.15μM R08 exp513">
{{:chemogenomics:comparison_plots:exp329_vs_exp513.png?nolink |}}
</modal>

<modal id="11" size="lg" title="Hydroxyurea 100μM R07 exp329  vs  Olaparib 4μM R08 exp512">
{{:chemogenomics:comparison_plots:exp329_vs_exp512.png?nolink |}}
</modal>

<modal id="12" size="lg" title="Hydroxyurea 100μM R07 exp329  vs  LLY-283 2.6μM R06 exp290">
{{:chemogenomics:comparison_plots:exp290_vs_exp329.png?nolink |}}
</modal>

<modal id="13" size="lg" title="Hydroxyurea 100μM R07 exp329  vs  Quercetin 20μM R08 exp517">
{{:chemogenomics:comparison_plots:exp329_vs_exp517.png?nolink |}}
</modal>

<modal id="14" size="lg" title="Hydroxyurea 100μM R07 exp329  vs  iCRT14 30μM R08 exp492">
{{:chemogenomics:comparison_plots:exp329_vs_exp492.png?nolink |}}
</modal>

<modal id="15" size="lg" title="Hydroxyurea 100μM R07 exp329  vs  UMK57 1μM R01 exp59">
{{:chemogenomics:comparison_plots:exp329_vs_exp59.png?nolink |}}
</modal>

<modal id="16" size="lg" title="Hydroxyurea 100μM R07 exp329  vs  MK-1775 0.32μM R02 exp75">
{{:chemogenomics:comparison_plots:exp329_vs_exp75.png?nolink |}}
</modal>

<modal id="17" size="lg" title="Hydroxyurea 100μM R07 exp329  vs  JQ1 0.8μM R08 exp435">
{{:chemogenomics:comparison_plots:exp329_vs_exp435.png?nolink |}}
</modal>

<modal id="18" size="lg" title="Hydroxyurea 100μM R07 exp329  vs  Vemurafenib 6.6μM R08 exp434">
{{:chemogenomics:comparison_plots:exp329_vs_exp434.png?nolink |}}
</modal>

<modal id="19" size="lg" title="Hydroxyurea 100μM R07 exp329  vs  TRAIL 50ng/ml R00 exp36">
{{:chemogenomics:comparison_plots:exp329_vs_exp36.png?nolink |}}
</modal>

<modal id="20" size="lg" title="Hydroxyurea 100μM R07 exp329  vs  Mitomycin-C 0.06μM R08 exp503">
{{:chemogenomics:comparison_plots:exp329_vs_exp503.png?nolink |}}
</modal>

<modal id="21" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  Hydroxyurea 100μM R07 exp329">
{{:chemogenomics:comparison_plots:exp329_vs_exp440.png?nolink |}}
</modal>

<modal id="22" size="lg" title="GSK-J4 1.5μM R08 exp441  vs  Hydroxyurea 100μM R07 exp329">
{{:chemogenomics:comparison_plots:exp329_vs_exp441.png?nolink |}}
</modal>

<modal id="23" size="lg" title="Deferoxamine 11μM R07 exp350  vs  Hydroxyurea 100μM R07 exp329">
{{:chemogenomics:comparison_plots:exp329_vs_exp350.png?nolink |}}
</modal>

<modal id="24" size="lg" title="Genistein 15μM R07 exp360  vs  Hydroxyurea 100μM R07 exp329">
{{:chemogenomics:comparison_plots:exp329_vs_exp360.png?nolink |}}
</modal>

<modal id="25" size="lg" title="Artemisinin 50μM R08 exp450  vs  Hydroxyurea 100μM R07 exp329">
{{:chemogenomics:comparison_plots:exp329_vs_exp450.png?nolink |}}
</modal>

<modal id="26" size="lg" title="Diepoxybutane 3μM R07 exp354  vs  Hydroxyurea 100μM R07 exp329">
{{:chemogenomics:comparison_plots:exp329_vs_exp354.png?nolink |}}
</modal>

<modal id="27" size="lg" title="CoCl2 18μM R07 exp346  vs  Hydroxyurea 100μM R07 exp329">
{{:chemogenomics:comparison_plots:exp329_vs_exp346.png?nolink |}}
</modal>

<modal id="28" size="lg" title="ABT-702 5μM plus Deferoxamine 11μM R07 exp321  vs  Hydroxyurea 100μM R07 exp329">
{{:chemogenomics:comparison_plots:exp321_vs_exp329.png?nolink |}}
</modal>

<modal id="29" size="lg" title="HMS-I2 10μM R06 exp288  vs  Hydroxyurea 100μM R07 exp329">
{{:chemogenomics:comparison_plots:exp288_vs_exp329.png?nolink |}}
</modal>

<modal id="30" size="lg" title="Atovaquone 15μM R08 exp451  vs  Hydroxyurea 100μM R07 exp329">
{{:chemogenomics:comparison_plots:exp329_vs_exp451.png?nolink |}}
</modal>

<modal id="31" size="lg" title="Cryptotanshinone 12μM R05 exp227  vs  Hydroxyurea 100μM R07 exp329">
{{:chemogenomics:comparison_plots:exp227_vs_exp329.png?nolink |}}
</modal>

<modal id="32" size="lg" title="CI-1040 9.5μM R08 exp472  vs  Hydroxyurea 100μM R07 exp329">
{{:chemogenomics:comparison_plots:exp329_vs_exp472.png?nolink |}}
</modal>

<modal id="33" size="lg" title="BML-284 0.09μM R08 exp460  vs  Hydroxyurea 100μM R07 exp329">
{{:chemogenomics:comparison_plots:exp329_vs_exp460.png?nolink |}}
</modal>

<modal id="34" size="lg" title="BI-D1870 3.15μM R02 exp66  vs  Hydroxyurea 100μM R07 exp329">
{{:chemogenomics:comparison_plots:exp329_vs_exp66.png?nolink |}}
</modal>

<modal id="35" size="lg" title="Dorsomorphin 5μM R07 exp357  vs  Hydroxyurea 100μM R07 exp329">
{{:chemogenomics:comparison_plots:exp329_vs_exp357.png?nolink |}}
</modal>

<modal id="36" size="lg" title="Calcium Ionophore 0.4μM R07 exp342  vs  Hydroxyurea 100μM R07 exp329">
{{:chemogenomics:comparison_plots:exp329_vs_exp342.png?nolink |}}
</modal>

<modal id="37" size="lg" title="AICAR 240μM R05 exp211  vs  Hydroxyurea 100μM R07 exp329">
{{:chemogenomics:comparison_plots:exp211_vs_exp329.png?nolink |}}
</modal>

<modal id="38" size="lg" title="CR131-b 0.005μM R08 exp474  vs  Hydroxyurea 100μM R07 exp329">
{{:chemogenomics:comparison_plots:exp329_vs_exp474.png?nolink |}}
</modal>

<modal id="39" size="lg" title="42°C R08 exp539  vs  Hydroxyurea 100μM R07 exp329">
{{:chemogenomics:comparison_plots:exp329_vs_exp539.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">
^GO Term^Fold Change^Genes^
|GATOR1 complex|571.69|NPRL2,NPRL3|
|DNA repair|9.71|PRIMPOL,RECQL5,KAT7,PDS5B,RIF1,WDR33,NSMCE3,ZBTB7A|
|DNA metabolic process|7.19|PRIMPOL,RRM2,RECQL5,KAT7,PDS5B,RIF1,WDR33,NSMCE3,ZBTB7A|
</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">
^GO Term^Fold Change^Genes^
|mitochondrial translation|61.98|MRPL23,MRPL53,MRPS21,MRPS2,YARS2,MRPL43,MRPS18A,DARS2,MRPL21,GFM2,MRPS22,MRPL17|
|mitochondrial large ribosomal subunit|60.29|MRPL23,MRPL53,MRPL43,MRPS18A,MRPL21,MRPL17|
|organellar large ribosomal subunit|60.29|MRPL23,MRPL53,MRPL43,MRPS18A,MRPL21,MRPL17|
|mitochondrial gene expression|59.64|MRPL23,MRPL53,HSD17B10,MRPS21,MRPS2,YARS2,MRPL43,FASTKD5,MRPS18A,DARS2,SUPV3L1,MRPL21,GFM2,MRPS22,MRPL17|
|organellar ribosome|56.52|MRPL23,MRPL53,MRPS21,MRPS2,MRPL43,MRPS18A,MRPL21,MRPS22,MRPL17|
|mitochondrial ribosome|50.24|MRPL23,MRPL53,MRPS21,MRPS2,MRPL43,MRPS18A,MRPL21,MRPL17|
|mitochondrial protein-containing complex|30.14|MRPL23,MRPL53,HSD17B10,COX7B,MRPS21,MRPS2,UQCRC1,NDUFA2,MRPL43,NDUFB11,MRPS18A,SUPV3L1,MRPL21,MRPS22,MRPL17|
|ribosomal subunit|28.58|MRPL23,MRPL53,MRPS21,MRPS2,MRPL43,MRPS18A,MRPL21,MRPS22,MRPL17|
|ribosome|22.82|MRPL23,MRPL53,MRPS21,MRPS2,MRPL43,MRPS18A,MRPL21,MRPS22,MRPL17|
|translation|19.96|MRPL23,MRPL53,EIF4A1,MRPS21,MRPS2,YARS2,MRPL43,MRPS18A,DARS2,MRPL21,GFM2,MRPS22,MRPL17|
|peptide biosynthetic process|18.66|MRPL23,MRPL53,EIF4A1,MRPS21,MRPS2,YARS2,MRPL43,MRPS18A,DARS2,MRPL21,GFM2,MRPS22,MRPL17|
|mitochondrial matrix|18.62|MRPL23,MRPL53,HSD17B10,MRPS21,MRPS2,YARS2,MRM2,MRPL43,FASTKD5,MRPS18A,DARS2,SUPV3L1,MRPL21,GFM2,MRPS22,MRPL17|
|mitochondrial inner membrane|15.65|MRPL23,MRPL53,COX7B,MRPS21,MRPS2,UQCRC1,NDUFA2,MRPL43,NDUFB11,MRPS18A,MRPL21,MRPS22,MRPL17|
|peptide metabolic process|15.06|MRPL23,MRPL53,EIF4A1,MRPS21,MRPS2,YARS2,MRPL43,MRPS18A,DARS2,MRPL21,GFM2,MRPS22,MRPL17|
|amide biosynthetic process|14.20|MRPL23,MRPL53,EIF4A1,MRPS21,MRPS2,YARS2,MRPL43,MRPS18A,DARS2,MRPL21,GFM2,MRPS22,MRPL17|
|organelle inner membrane|14.06|MRPL23,MRPL53,COX7B,MRPS21,MRPS2,UQCRC1,NDUFA2,MRPL43,NDUFB11,MRPS18A,MRPL21,MRPS22,MRPL17|
|amide metabolic process|10.18|MRPL23,MRPL53,EIF4A1,AASDHPPT,MRPS21,MRPS2,YARS2,MRPL43,MRPS18A,DARS2,MRPL21,GFM2,MRPS22,MRPL17|
|mitochondrial membrane|10.18|MRPL23,MRPL53,COX7B,MRPS21,MRPS2,UQCRC1,NDUFA2,MRPL43,NDUFB11,MRPS18A,MRPL21,MRPS22,MRPL17|
|mitochondrial envelope|9.55|MRPL23,MRPL53,COX7B,MRPS21,MRPS2,UQCRC1,NDUFA2,MRPL43,NDUFB11,MRPS18A,MRPL21,MRPS22,MRPL17|
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