DKK1 89ng/ml R08 exp477 [The Human Chemical-Genetic Interaction Map Project]

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====== DKK1 89ng/ml R08 exp477 ======
==== Mechanism of Action ====
Dickkopf1 (DKK1), recombinant protein inhibitor of WNT signaling, binds LRP5/LRP6 co-receptor and KRM1
  * **<color #00a2e8>Class / Subclass 1:</color>** Signal Transduction / GPCR Antagonist




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%N/A%%
    * **<color #00a2e8>Synonyms:</color>** N/A
    * **<color #00a2e8>CAS #:</color>** N/A
    * **<color #00a2e8>PubChem CID:</color>** N/A
    * **<color #00a2e8>IUPAC:</color>** %%N/A%%
    * **<color #00a2e8>INCHI Name:</color>** N/A
    * **<color #00a2e8>INCHI Key:</color>** N/A
    * **<color #00a2e8>Molecular Weight:</color>** 27.22kDa
    * **<color #00a2e8>Canonical SMILES:</color>** N/A
    * **<color #00a2e8>Isomeric SMILES:</color>** N/A
    * **<color #00a2e8>Molecular Formula:</color>** Met 2-His 266
{{:chemogenomics:structures:chem-0286.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Sino Biological
    * **<color #00a2e8>Catalog #:</color>** 10170-H08H
    * **<color #00a2e8>Lot #:</color>** LC09DE3010
</panel>


<panel title='Compound Characterization' collapsed='true'>
Characterization data not available.
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** DKK1
    * **<color #00a2e8>Min:</color>** -7.2933; **<color #00a2e8>Max:</color>** 24.4479
{{:chemogenomics:dose_response:dr_527.png?nolink&500 |}}
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|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |N/A    |
| IC30  |N/A    |
| IC40  |N/A    |
| IC50  |N/A    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 08
    * **<color #00a2e8>Dose</color>**: 89ng/mL
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 7.1
    * **<color #00a2e8>Numbers of reads</color>**: 16422937


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|0/0|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/DKK1_89_ng_per_mL_Round-8_exp477.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="default" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="default" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='DKK1 89ng/ml R08 exp477'>
{{:chemogenomics:cranks_plots:exp477.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:S:SEC16A|SEC16A]]|-2.44|0.65|
|[[:human_genes:S:ST8SIA6|ST8SIA6]]|-2.38|0.55|
|[[:human_genes:V:VPS25|VPS25]]|-2.35|0.80|
|[[:human_genes:C:CCDC59|CCDC59]]|-2.25|0.55|
|[[:human_genes:S:SCAP|SCAP]]|-2.25|0.55|
|[[:human_genes:C:CLSTN2|CLSTN2]]|-2.20|0.55|
|[[:human_genes:A:ATIC|ATIC]]|-2.12|0.65|
|[[:human_genes:A:ATP2A2|ATP2A2]]|-2.10|0.86|
|[[:human_genes:H:HMGB4|HMGB4]]|-2.10|0.65|
|[[:human_genes:S:SH2B1|SH2B1]]|-2.04|0.65|
|[[:human_genes:C:CNOT4|CNOT4]]|-2.03|0.65|
|[[:human_genes:A:ADCK3|ADCK3]]|-1.99|0.80|
|[[:human_genes:C:CCIN|CCIN]]|-1.99|0.65|
|[[:human_genes:P:PSTPIP2|PSTPIP2]]|-1.99|0.65|
|[[:human_genes:C:CHKA|CHKA]]|-1.98|0.65|
|[[:human_genes:F:FAM98B|FAM98B]]|-1.94|0.80|
|[[:human_genes:V:VPS4B|VPS4B]]|-1.94|0.80|
|[[:human_genes:C:COA5|COA5]]|-1.93|0.80|
|[[:human_genes:P:POLD2|POLD2]]|-1.93|0.80|
|[[:human_genes:F:FAM53C|FAM53C]]|-1.92|0.80|
|[[:human_genes:C:CCND2|CCND2]]|-1.90|0.80|
|[[:human_genes:B:BOP1|BOP1]]|-1.90|0.83|
|[[:human_genes:Q:QRICH1|QRICH1]]|-1.88|0.80|
|[[:human_genes:A:ALG5|ALG5]]|-1.84|0.80|
|[[:human_genes:Q:QARS|QARS]]|-1.84|0.86|
|[[:human_genes:Z:ZNF431|ZNF431]]|-1.82|0.80|
|[[:human_genes:V:VPS33A|VPS33A]]|-1.81|0.80|
|[[:human_genes:O:OPTN|OPTN]]|-1.81|0.80|
|[[:human_genes:M:MRPL1|MRPL1]]|-1.80|0.80|
|[[:human_genes:R:RSRC2|RSRC2]]|-1.79|0.88|
|[[:human_genes:G:GPATCH1|GPATCH1]]|1.86|0.74|
|[[:human_genes:D:DNAJC11|DNAJC11]]|1.86|0.83|
|[[:human_genes:P:PSMD6|PSMD6]]|1.86|0.89|
|[[:human_genes:M:MTCP1|MTCP1]]|1.87|0.74|
|[[:human_genes:R:RAPH1|RAPH1]]|1.87|0.74|
|[[:human_genes:P:PSMD12|PSMD12]]|1.87|0.89|
|[[:human_genes:R:RNF40|RNF40]]|1.88|0.74|
|[[:human_genes:R:RPL13|RPL13]]|1.88|0.89|
|[[:human_genes:A:AKAP2|AKAP2]]|1.89|0.74|
|[[:human_genes:H:HNRNPH3|HNRNPH3]]|1.91|0.74|
|[[:human_genes:H:HCFC1|HCFC1]]|1.91|0.89|
|[[:human_genes:P:POLR2E|POLR2E]]|1.91|0.89|
|[[:human_genes:C:CCER1|CCER1]]|1.92|0.74|
|[[:human_genes:A:ABCA5|ABCA5]]|1.92|0.74|
|[[:human_genes:M:MGST1|MGST1]]|1.93|0.74|
|[[:human_genes:R:RPL27A|RPL27A]]|1.96|0.89|
|[[:human_genes:T:THAP7|THAP7]]|1.96|0.74|
|[[:human_genes:P:P2RX7|P2RX7]]|1.97|0.74|
|[[:human_genes:C:CTNND1|CTNND1]]|1.97|0.74|
|[[:human_genes:T:TOB2|TOB2]]|1.98|0.74|
|[[:human_genes:H:HTR7|HTR7]]|1.98|0.74|
|[[:human_genes:G:GPAM|GPAM]]|1.98|0.74|
|[[:human_genes:F:FREM1|FREM1]]|1.99|0.74|
|[[:human_genes:P:PRPF19|PRPF19]]|2.07|0.81|
|[[:human_genes:P:PRR5|PRR5]]|2.10|0.74|
|[[:human_genes:H:HEATR1|HEATR1]]|2.13|0.74|
|[[:human_genes:A:ARPC1A|ARPC1A]]|2.17|0.74|
|[[:human_genes:N:NOL6|NOL6]]|2.24|0.74|
|[[:human_genes:U:UBE2I|UBE2I]]|2.33|0.74|
|[[:human_genes:P:PDCD11|PDCD11]]|2.51|0.74|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
No correlation data above threshold. (correlation > 0.05)
</modal>


<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">No GO term hits below threshold. (FDR <0.05)</modal>