WNT3A 44ng/ml R08 exp537 [The Human Chemical-Genetic Interaction Map Project]

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====== WNT3A 44ng/ml R08 exp537 ======
==== Mechanism of Action ====
Ligand for Frizzled receptor complex, stabilizes ‘_-catenin, induces TCS/LEF-dependent transcription
  * **<color #00a2e8>Class / Subclass 1:</color>** Signal Transduction / GPCR Agonist




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%N/A%%
    * **<color #00a2e8>Synonyms:</color>** MGC119418; MGC119419; MGC119420; protein Wnt-3a; wingless-type MMTV integration site family, member 3A; Wnt3a; Wnt-3a; MGC119418; MGC119419; MGC119420; protein Wnt-3a; wingless-type MMTV integration site family, member 3A; Wnt3a; Wnt-3a
    * **<color #00a2e8>CAS #:</color>** N/A
    * **<color #00a2e8>PubChem CID:</color>** N/A
    * **<color #00a2e8>IUPAC:</color>** %%N/A%%
    * **<color #00a2e8>INCHI Name:</color>** N/A
    * **<color #00a2e8>INCHI Key:</color>** N/A
    * **<color #00a2e8>Molecular Weight:</color>** 37.4kDa
    * **<color #00a2e8>Canonical SMILES:</color>** N/A
    * **<color #00a2e8>Isomeric SMILES:</color>** N/A
    * **<color #00a2e8>Molecular Formula:</color>** MSYPIWWSLA VGPQYSSLGS QPILCASIPG LVPKQLRFCR NYVEIMPSVA EGIKIGIQEC QHQFRGRRWN CTTVHDSLAI FGPVLDKATR ESAFVHAIAS AGVAFAVTRS CAEGTAAICG CSSRHQGSPG KGWKWGGCSE DIEFGGMVSR EFADARENRP DARSAMNRHN NEAGRQAIAS HMHLKCKCHG LSGSCEVKTC WWSQPDFRAI GDFLKDKYDS ASEMVVEKHR ESRGWVETLR PRYTYFKVPT ERDLVYYEAS PNFCEPNPET GSFGTRDRTC NVSSHGIDGC DLLCCGRGHN ARAERRREKC RCVFHWCCYV SCQECTRVYD VHTCK
{{:chemogenomics:structures:chem-0341.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** R&D system
    * **<color #00a2e8>Catalog #:</color>** PSM5036
    * **<color #00a2e8>Lot #:</color>** RSK8018031
</panel>


<panel title='Compound Characterization' collapsed='true'>
Characterization data not available.
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** Wnt_3a
    * **<color #00a2e8>Min:</color>** -15.7852; **<color #00a2e8>Max:</color>** 40.2171
{{:chemogenomics:dose_response:dr_596.png?nolink&500 |}}
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|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |N/A    |
| IC30  |N/A    |
| IC40  |N/A    |
| IC50  |N/A    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 08
    * **<color #00a2e8>Dose</color>**: 44ng/mL
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 7.2
    * **<color #00a2e8>Numbers of reads</color>**: 15772202


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|0/0|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/WNT3A_44_ng_per_mL_Round-8_exp537.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="primary" size="sm" modal="modal_go_sensitive">View</button>|<button type="default" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='WNT3A 44ng/ml R08 exp537'>
{{:chemogenomics:cranks_plots:exp537.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:Z:ZNF708|ZNF708]]|-2.67|0.24|
|[[:human_genes:Y:YARS|YARS]]|-2.51|0.62|
|[[:human_genes:Q:QRICH1|QRICH1]]|-2.45|0.24|
|[[:human_genes:S:SNCB|SNCB]]|-2.45|0.24|
|[[:human_genes:C:CDIPT|CDIPT]]|-2.38|0.59|
|[[:human_genes:C:CEPT1|CEPT1]]|-2.34|0.24|
|[[:human_genes:P:PTAR1|PTAR1]]|-2.27|0.45|
|[[:human_genes:S:SMAD3|SMAD3]]|-2.15|0.45|
|[[:human_genes:A:ADIPOR2|ADIPOR2]]|-2.15|0.45|
|[[:human_genes:A:ATP6V1D|ATP6V1D]]|-2.08|0.59|
|[[:human_genes:R:RNF111|RNF111]]|-2.07|0.59|
|[[:human_genes:M:METTL7B|METTL7B]]|-2.04|0.59|
|[[:human_genes:A:ABR|ABR]]|-2.02|0.59|
|[[:human_genes:V:VPS33B|VPS33B]]|-2.01|0.59|
|[[:human_genes:E:EPT1|EPT1]]|-1.99|0.66|
|[[:human_genes:S:SEC22B|SEC22B]]|-1.98|0.59|
|[[:human_genes:T:TUBD1|TUBD1]]|-1.98|0.59|
|[[:human_genes:K:KARS|KARS]]|-1.96|0.77|
|[[:human_genes:R:RPE|RPE]]|-1.96|0.73|
|[[:human_genes:F:FSCN3|FSCN3]]|-1.96|0.74|
|[[:human_genes:G:GFM2|GFM2]]|-1.93|0.62|
|[[:human_genes:M:MAP1A|MAP1A]]|-1.92|0.74|
|[[:human_genes:L:L3HYPDH|L3HYPDH]]|-1.91|0.62|
|[[:human_genes:S:STK39|STK39]]|-1.91|0.62|
|[[:human_genes:V:VRK1|VRK1]]|-1.91|0.74|
|[[:human_genes:G:GEMIN2|GEMIN2]]|-1.90|0.74|
|[[:human_genes:P:PIK3C3|PIK3C3]]|-1.89|0.76|
|[[:human_genes:C:CDCA2|CDCA2]]|-1.83|0.73|
|[[:human_genes:C:C10orf32|C10orf32]]|-1.83|0.73|
|[[:human_genes:C:CFAP45|CFAP45]]|-1.83|0.87|
|[[:human_genes:C:CXorf51A|CXorf51A]]|1.94|0.61|
|[[:human_genes:D:DHX15|DHX15]]|1.96|0.78|
|[[:human_genes:S:SMC2|SMC2]]|1.96|0.78|
|[[:human_genes:R:RPL26|RPL26]]|1.96|0.62|
|[[:human_genes:K:KLHL41|KLHL41]]|1.99|0.61|
|[[:human_genes:N:NUP153|NUP153]]|2.00|0.61|
|[[:human_genes:A:ALKBH1|ALKBH1]]|2.00|0.56|
|[[:human_genes:S:ST8SIA1|ST8SIA1]]|2.00|0.56|
|[[:human_genes:D:DOCK6|DOCK6]]|2.01|0.61|
|[[:human_genes:P:PTRH1|PTRH1]]|2.02|0.56|
|[[:human_genes:S:SULF1|SULF1]]|2.03|0.56|
|[[:human_genes:G:GABRA5|GABRA5]]|2.05|0.56|
|[[:human_genes:U:UBA1|UBA1]]|2.05|0.78|
|[[:human_genes:M:MAFB|MAFB]]|2.08|0.56|
|[[:human_genes:E:EP300|EP300]]|2.14|0.61|
|[[:human_genes:P:PDSS1|PDSS1]]|2.14|0.56|
|[[:human_genes:H:HSPA5|HSPA5]]|2.14|0.78|
|[[:human_genes:N:NUP88|NUP88]]|2.16|0.56|
|[[:human_genes:F:FRY|FRY]]|2.20|0.56|
|[[:human_genes:P:PES1|PES1]]|2.25|0.75|
|[[:human_genes:T:TBC1D3I|TBC1D3I]]|2.32|0.61|
|[[:human_genes:M:MAU2|MAU2]]|2.32|0.61|
|[[:human_genes:T:TBC1D3E|TBC1D3E]]|2.33|0.61|
|[[:human_genes:T:TBC1D3K|TBC1D3K]]|2.33|0.61|
|[[:human_genes:T:TBC1D3L|TBC1D3L]]|2.33|0.61|
|[[:human_genes:A:ATP5L2|ATP5L2]]|2.41|0.56|
|[[:human_genes:A:ADSS|ADSS]]|2.43|0.56|
|[[:human_genes:I:IQGAP3|IQGAP3]]|2.53|0.32|
|[[:human_genes:R:RPL5|RPL5]]|2.57|0.56|
|[[:human_genes:P:POLR2L|POLR2L]]|2.63|0.75|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|0.06|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp132|Metformin 40μM R03 exp132]]|0.054|<button type="primary" size="small" modal="2">View</button>|
</modal>


<modal id="1" size="lg" title="Bisphenol F 50μM R08 exp457  vs  WNT3A 44ng/ml R08 exp537">
{{:chemogenomics:comparison_plots:exp457_vs_exp537.png?nolink |}}
</modal>

<modal id="2" size="lg" title="Metformin 40μM R03 exp132  vs  WNT3A 44ng/ml R08 exp537">
{{:chemogenomics:comparison_plots:exp132_vs_exp537.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">
^GO Term^Fold Change^Genes^
|CDP-alcohol phosphatidyltransferase activity|273.12|CDIPT,CEPT1,SELENOI|
|phosphotransferase activity, for other substituted phosphate groups|91.04|CDIPT,CEPT1,SELENOI|
</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">No GO term hits below threshold. (FDR <0.05)</modal>