A3GALT2

Entrez Summary: N/A
UniProt Summary: Synthesizes the galactose-alpha(1,3)-galactose group on the glycosphingolipid isoglobotrihexosylceramide or isogloboside 3 (iGb3) by catalyzing the transfer of galactose from UDP-Galactose to its acceptor molecule Gal-beta-1,4-Glc-ceramide. Can also catalyze the addition of galactose to iGb3 itself to form polygalactose structures. {ECO:0000305|PubMed:23378701}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

N-acetyllactosaminide 3-alpha-galactosyltransferase activity
alpha-1,3-galactosyltransferase activity
lipid glycosylation
cellular response to manganese ion
transferase activity, transferring glycosyl groups
response to manganese ion
glycosphingolipid biosynthetic process
glycolipid biosynthetic process
glycosphingolipid metabolic process
sphingolipid biosynthetic process
Golgi cisterna membrane
glycolipid metabolic process
liposaccharide metabolic process
membrane lipid biosynthetic process
vesicle
sphingolipid metabolic process
cellular response to metal ion
lipid modification
membrane lipid metabolic process
cellular response to inorganic substance
glycosylation
response to metal ion
carbohydrate metabolic process
response to inorganic substance
lipid biosynthetic process
carbohydrate derivative biosynthetic process
cellular lipid metabolic process
Golgi apparatus
carbohydrate derivative metabolic process
lipid metabolic process
organonitrogen compound biosynthetic process