A4GNT

Entrez Summary: N/A
UniProt Summary: Catalyzes the transfer of N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans (PubMed:10430883). Necessary for the synthesis of type III mucin which is specifically produced in the stomach, duodenum, and pancreatic duct (PubMed:10430883). May protect against inflammation-associated gastric adenocarcinomas (By similarity). {ECO:0000250|UniProtKB:Q14BT6, ECO:0000269|PubMed:10430883}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Rucaparib 6.5μM R08 exp520	-1.79
Oligomycin-A 20μM R00 exp26	1.84

Gb3 synth
Gly transf sug

acetylglucosaminyltransferase activity
O-glycan processing
protein O-linked glycosylation
negative regulation of epithelial cell proliferation
macromolecule glycosylation
protein glycosylation
glycosylation
glycoprotein biosynthetic process
regulation of epithelial cell proliferation
glycoprotein metabolic process
carbohydrate metabolic process
Golgi membrane
carbohydrate derivative biosynthetic process
negative regulation of cell population proliferation
carbohydrate derivative metabolic process
organonitrogen compound biosynthetic process
regulation of cell population proliferation
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
membrane