AATK

Gene Information
  • Official Symbol: AATK
  • Official Name: apoptosis associated tyrosine kinase
  • Aliases and Previous Symbols: N/A
  • Entrez ID: 9625
  • UniProt: Q6ZMQ8
  • Interactions: BioGRID
  • PubMed articles: Open PubMed
  • OMIM: Open OMIM
Function Summary
  • Entrez Summary: The protein encoded by this gene contains a tyrosine kinase domain at the N-terminus and a proline-rich domain at the C-terminus. This gene is induced during apoptosis, and expression of this gene may be a necessary pre-requisite for the induction of growth arrest and/or apoptosis of myeloid precursor cells. This gene has been shown to produce neuronal differentiation in a neuroblastoma cell line. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011].
  • UniProt Summary: May be involved in neuronal differentiation. {ECO:0000269|PubMed:10837911}.

Pfam Domains GO Terms


CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Essentiality in NALM6
  • Essentiality Rank: 3336
  • Expression level (log2 read counts): -5.28

Expression Distribution

  • Last modified: 2026/01/07 22:36
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