ABCA5 [The Human Chemical-Genetic Interaction Map Project]

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======= ABCA5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ABCA5
  * **<color #00a2e8>Official Name</color>**: ATP binding cassette subfamily A member 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23461|23461]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8WWZ7|Q8WWZ7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ABCA5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ABCA5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612503|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This encoded protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This gene is clustered among 4 other ABC1 family members on 17q24, but neither the substrate nor the function of this gene is known. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in the processing of autolysosomes. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ABC tran|
|ABC2 membrane 3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of macrophage derived foam cell differentiation|
|reverse cholesterol transport|
|high-density lipoprotein particle remodeling|
|cholesterol efflux|
|protein-lipid complex remodeling|
|plasma lipoprotein particle remodeling|
|protein-containing complex remodeling|
|regulation of macrophage derived foam cell differentiation|
|lipid transporter activity|
|plasma lipoprotein particle organization|
|protein-lipid complex subunit organization|
|ATPase-coupled transmembrane transporter activity|
|cholesterol transport|
|sterol transport|
|regulation of plasma lipoprotein particle levels|
|late endosome membrane|
|late endosome|
|organic hydroxy compound transport|
|ATPase activity|
|lysosome|
|lipid transport|
|lysosomal membrane|
|lipid localization|
|extracellular structure organization|
|Golgi membrane|
|intracellular membrane-bounded organelle|
|negative regulation of cell differentiation|
|negative regulation of developmental process|
|ion transmembrane transport|
|Golgi apparatus|
|transmembrane transport|
|ion transport|
|ATP binding|
|regulation of cell differentiation|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|-2.19|
|[[:results:exp393|Resminostat 0.5μM R07 exp393]]|-1.72|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|1.71|
|[[:results:exp69|Deguelin 0.05μM R02 exp69]]|1.76|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|1.85|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.91|
|[[:results:exp477|DKK1 89ng/ml R08 exp477]]|1.92|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|2.12|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.571|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17663
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ABCA5 Expression in NALM6 Cells: 4.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>