ABCB6

Official Symbol: ABCB6
Official Name: ATP binding cassette subfamily B member 6 (Langereis blood group)
Aliases and Previous Symbols: N/A
Entrez ID: 10058
UniProt: Q9NP58
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across extra- and intra-cellular membranes. This protein is a member of the heavy metal importer subfamily and plays a role in porphyrin transport. This gene is the molecular basis of the Langereis (Lan) blood group antigen and mutations in this gene underlie familial pseudohyperkalemia and dyschromatosis universalis hereditaria. [provided by RefSeq, Mar 2017].
UniProt Summary: Binds heme and porphyrins and functions in their ATP- dependent uptake into the mitochondria. Plays a crucial role in heme synthesis. {ECO:0000269|PubMed:10837493, ECO:0000269|PubMed:17006453}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
2-Methoxyestradiol 0.55μM R07 exp310	1.7
Lenalidomide 20μM R07 exp375	1.93

heme transmembrane transport
ATPase-coupled heme transmembrane transporter activity
efflux transmembrane transporter activity
ATP-binding cassette (ABC) transporter complex
mitochondrial envelope
heme transport
iron coordination entity transport
iron ion transmembrane transport
integral component of mitochondrial outer membrane
porphyrin-containing compound biosynthetic process
vacuolar membrane
tetrapyrrole biosynthetic process
porphyrin-containing compound metabolic process
cofactor transport
ATPase-coupled transmembrane transporter activity
tetrapyrrole metabolic process
cellular iron ion homeostasis
iron ion transport
iron ion homeostasis
cellular transition metal ion homeostasis
transition metal ion transport
transition metal ion homeostasis
heme binding
mitochondrial outer membrane
cofactor biosynthetic process
endosome membrane
ATPase activity
endosome
skin development
cofactor metabolic process
cellular metal ion homeostasis
inorganic cation transmembrane transport
cation transmembrane transport
Golgi membrane
metal ion homeostasis
cellular cation homeostasis
metal ion transport
cellular ion homeostasis
inorganic ion transmembrane transport
cation homeostasis