ABCC1 [The Human Chemical-Genetic Interaction Map Project]

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======= ABCC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ABCC1
  * **<color #00a2e8>Official Name</color>**: ATP binding cassette subfamily C member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4363|4363]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P33527|P33527]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ABCC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ABCC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/158343|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown. [provided by RefSeq, Apr 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ABC membrane|
|ABC tran|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ATPase-coupled glutathione S-conjugate transmembrane transporter activity|
|glutathione transmembrane transporter activity|
|leukotriene transport|
|tripeptide transmembrane transport|
|ATPase-coupled lipid transmembrane transporter activity|
|glutathione transmembrane transport|
|ATPase-coupled vitamin B12 transmembrane transporter activity|
|sphingolipid translocation|
|glutathione transport|
|tripeptide transport|
|ATPase-coupled xenobiotic transmembrane transporter activity|
|cobalamin transport|
|oligopeptide transmembrane transport|
|oligopeptide transport|
|xenobiotic transport|
|cobalamin metabolic process|
|modified amino acid transport|
|vacuolar membrane|
|icosanoid transport|
|leukotriene metabolic process|
|fatty acid derivative transport|
|vitamin transport|
|phospholipid translocation|
|lipid translocation|
|sulfur compound transport|
|cofactor transport|
|regulation of membrane lipid distribution|
|ATPase-coupled transmembrane transporter activity|
|tetrapyrrole metabolic process|
|drug transmembrane transport|
|water-soluble vitamin metabolic process|
|phospholipid transport|
|icosanoid metabolic process|
|organophosphate ester transport|
|vitamin metabolic process|
|positive regulation of inflammatory response|
|drug transport|
|fatty acid derivative metabolic process|
|basolateral plasma membrane|
|cell chemotaxis|
|ATPase activity|
|anion transmembrane transport|
|carboxylic acid transport|
|organic acid transport|
|lipid transport|
|lipid localization|
|regulation of inflammatory response|
|cofactor metabolic process|
|organic anion transport|
|positive regulation of defense response|
|drug metabolic process|
|chemotaxis|
|taxis|
|anion transport|
|positive regulation of response to external stimulus|
|regulation of defense response|
|membrane organization|
|carboxylic acid metabolic process|
|ion transmembrane transport|
|cell migration|
|oxoacid metabolic process|
|response to drug|
|organic acid metabolic process|
|localization of cell|
|cell motility|
|regulation of response to external stimulus|
|transmembrane transport|
|locomotion|
|ion transport|
|integral component of plasma membrane|
|regulation of response to stress|
|ATP binding|
|peptide transport|
|movement of cell or subcellular component|
|amide transport|
|small molecule metabolic process|
|nitrogen compound transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-7.22|
|[[:results:exp292|Menadione 5μM R06 exp292]]|-5.84|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-5.26|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-5.09|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|-4.55|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|-4.25|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-3.98|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-3.85|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|-3.84|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|-3.29|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|-3.24|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-2.9|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|-2.89|
|[[:results:exp275|Citral 75μM R06 exp275]]|-2.7|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|-2.28|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-2.12|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|-1.95|
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|-1.92|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|-1.86|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|-1.8|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-1.79|
|[[:results:exp187|proTAME 5μM R04 exp187]]|-1.78|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-1.74|
|[[:results:exp274|Citral 50μM R06 exp274]]|-1.73|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|-1.7|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|-1.7|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|1.82|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|1.87|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|3.07|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|4.05|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13302
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ABCC1 Expression in NALM6 Cells: 7.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>