ABCC1

Entrez Summary: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown. [provided by RefSeq, Apr 2012].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Rapamycin 10μM R00 exp30	-7.22
Menadione 5μM R06 exp292	-5.84
Thimerosal 0.85μM R08 exp529	-5.26
Vincristine 0.0005μM R04 exp190	-5.09
YM155 0.001μM R08 exp432	-4.55
Etoposide 0.1μM R05 exp198	-4.25
Arsenate 40μM R06 exp264	-3.98
Colchicine 0.009μM R05 exp215	-3.85
UM0131023 0.05μM R05 exp248	-3.84
Arsenic trioxide 60μM R08 exp449	-3.29
Ibrutinib 10μM R08 exp442	-3.24
Docosahexaenoic-acid 50μM R07 exp356	-2.9
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	-2.89
Citral 75μM R06 exp275	-2.7
Apcin 25μM plus proTAME 2μM R04 exp177	-2.28
LY2090314 0.003μM R08 exp499	-2.12
CCT251545 20μM R07 exp326	-1.95
4-Nitroquinoline-1-oxide 0.5μM R08 exp446	-1.92
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	-1.86
Alpha-Amanitin 0.5μM R00 exp5	-1.8
Cryptotanshinone 12μM R05 exp227	-1.79
proTAME 5μM R04 exp187	-1.78
LLY-283 2.6μM R06 exp290	-1.74
Citral 50μM R06 exp274	-1.73
Talazoparib 0.006μM R06 exp299	-1.7
Tunicamycin 0.04 to 0.075μM on day4 R07 exp419	-1.7
Rotenone 20μM R00 exp34	1.82
Cytochalasin-B 5μM R07 exp349	1.87
Deferoxamine 11μM R07 exp350	3.07
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	4.05

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ABC membrane
ABC tran

ATPase-coupled glutathione S-conjugate transmembrane transporter activity
glutathione transmembrane transporter activity
leukotriene transport
tripeptide transmembrane transport
ATPase-coupled lipid transmembrane transporter activity
glutathione transmembrane transport
ATPase-coupled vitamin B12 transmembrane transporter activity
sphingolipid translocation
glutathione transport
tripeptide transport
ATPase-coupled xenobiotic transmembrane transporter activity
cobalamin transport
oligopeptide transmembrane transport
oligopeptide transport
xenobiotic transport
cobalamin metabolic process
modified amino acid transport
vacuolar membrane
icosanoid transport
leukotriene metabolic process
fatty acid derivative transport
vitamin transport
phospholipid translocation
lipid translocation
sulfur compound transport
cofactor transport
regulation of membrane lipid distribution
ATPase-coupled transmembrane transporter activity
tetrapyrrole metabolic process
drug transmembrane transport
water-soluble vitamin metabolic process
phospholipid transport
icosanoid metabolic process
organophosphate ester transport
vitamin metabolic process
positive regulation of inflammatory response
drug transport
fatty acid derivative metabolic process
basolateral plasma membrane
cell chemotaxis