ABCG1 [The Human Chemical-Genetic Interaction Map Project]

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======= ABCG1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ABCG1
  * **<color #00a2e8>Official Name</color>**: ATP binding cassette subfamily G member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9619|9619]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P45844|P45844]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ABCG1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ABCG1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603076|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ABC2 membrane|
|ABC tran|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ATPase-coupled sterol transmembrane transporter activity|
|detection of hormone stimulus|
|cellular response to high density lipoprotein particle stimulus|
|glycoprotein transport|
|detection of endogenous stimulus|
|positive regulation of cholesterol biosynthetic process|
|positive regulation of sterol biosynthetic process|
|toxin transmembrane transporter activity|
|positive regulation of cholesterol metabolic process|
|negative regulation of cholesterol storage|
|phospholipid homeostasis|
|amyloid precursor protein catabolic process|
|regulation of cholesterol esterification|
|phospholipid efflux|
|negative regulation of macrophage derived foam cell differentiation|
|low-density lipoprotein particle remodeling|
|positive regulation of amyloid-beta formation|
|regulation of cholesterol storage|
|reverse cholesterol transport|
|phospholipid transporter activity|
|intracellular cholesterol transport|
|positive regulation of cholesterol efflux|
|intracellular sterol transport|
|high-density lipoprotein particle remodeling|
|positive regulation of steroid biosynthetic process|
|cholesterol transfer activity|
|amyloid precursor protein metabolic process|
|negative regulation of lipid storage|
|positive regulation of amyloid precursor protein catabolic process|
|cholesterol efflux|
|positive regulation of cholesterol transport|
|regulation of cholesterol efflux|
|positive regulation of sterol transport|
|positive regulation of alcohol biosynthetic process|
|regulation of amyloid-beta formation|
|positive regulation of steroid metabolic process|
|protein-lipid complex remodeling|
|plasma lipoprotein particle remodeling|
|protein-containing complex remodeling|
|cellular response to lipoprotein particle stimulus|
|regulation of macrophage derived foam cell differentiation|
|regulation of amyloid precursor protein catabolic process|
|intracellular lipid transport|
|ADP binding|
|toxin transport|
|negative regulation of lipid localization|
|regulation of sterol biosynthetic process|
|regulation of cholesterol biosynthetic process|
|plasma lipoprotein particle organization|
|regulation of cholesterol transport|
|regulation of lipid storage|
|regulation of sterol transport|
|protein-lipid complex subunit organization|
|cholesterol binding|
|ATPase-coupled transmembrane transporter activity|
|cholesterol transport|
|regulation of cholesterol metabolic process|
|anion homeostasis|
|positive regulation of lipid transport|
|sterol transport|
|carbohydrate derivative transport|
|regulation of plasma lipoprotein particle levels|
|regulation of alcohol biosynthetic process|
|cholesterol homeostasis|
|positive regulation of lipid biosynthetic process|
|sterol homeostasis|
|positive regulation of lipid localization|
|regulation of steroid biosynthetic process|
|phospholipid transport|
|phospholipid binding|
|regulation of lipid transport|
|regulation of steroid metabolic process|
|recycling endosome|
|cholesterol metabolic process|
|organophosphate ester transport|
|secondary alcohol metabolic process|
|lipid homeostasis|
|sterol metabolic process|
|regulation of lipid localization|
|positive regulation of small molecule metabolic process|
|organic hydroxy compound transport|
|positive regulation of lipid metabolic process|
|positive regulation of cellular amide metabolic process|
|protein dimerization activity|
|regulation of lipid biosynthetic process|
|ATPase activity|
|steroid metabolic process|
|endosome|
|positive regulation of protein secretion|
|positive regulation of peptide secretion|
|lipid transport|
|alcohol metabolic process|
|lipid localization|
|extracellular structure organization|
|external side of plasma membrane|
|regulation of lipid metabolic process|
|regulation of cellular amide metabolic process|
|positive regulation of secretion by cell|
|positive regulation of protein transport|
|regulation of small molecule metabolic process|
|positive regulation of secretion|
|organic hydroxy compound metabolic process|
|organic anion transport|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|protein heterodimerization activity|
|regulation of peptide secretion|
|detection of chemical stimulus|
|anion transport|
|Golgi membrane|
|detection of stimulus|
|regulation of protein transport|
|negative regulation of cell differentiation|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|ion homeostasis|
|regulation of secretion|
|response to lipid|
|protein homodimerization activity|
|response to hormone|
|endoplasmic reticulum membrane|
|negative regulation of developmental process|
|ion transmembrane transport|
|Golgi apparatus|
|positive regulation of transport|
|regulation of protein localization|
|chemical homeostasis|
|lipid metabolic process|
|mitochondrion|
|transmembrane transport|
|ion transport|
|response to endogenous stimulus|
|ATP binding|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|establishment of protein localization|
|homeostatic process|
|positive regulation of protein metabolic process|
|small molecule metabolic process|
|regulation of cell differentiation|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|regulation of transport|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-2.8|
|[[:results:exp169|BH1 1μM R04 exp169]]|1.79|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.97|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|2.17|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.81|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|3.51|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|4.11|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:nr1h2|NR1H2]]|0.427|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 16/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|2/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|1/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17302
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.79 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ABCG1 Expression in NALM6 Cells: 6.79'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>