ABCG1
Gene Information
- Official Symbol: ABCG1
- Official Name: ATP binding cassette subfamily G member 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 9619
- UniProt: P45844
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| ABC2 membrane |
| ABC tran |
GO Terms
| ATPase-coupled sterol transmembrane transporter activity |
| detection of hormone stimulus |
| cellular response to high density lipoprotein particle stimulus |
| glycoprotein transport |
| detection of endogenous stimulus |
| positive regulation of cholesterol biosynthetic process |
| positive regulation of sterol biosynthetic process |
| toxin transmembrane transporter activity |
| positive regulation of cholesterol metabolic process |
| negative regulation of cholesterol storage |
| phospholipid homeostasis |
| amyloid precursor protein catabolic process |
| regulation of cholesterol esterification |
| phospholipid efflux |
| negative regulation of macrophage derived foam cell differentiation |
| low-density lipoprotein particle remodeling |
| positive regulation of amyloid-beta formation |
| regulation of cholesterol storage |
| reverse cholesterol transport |
| phospholipid transporter activity |
| intracellular cholesterol transport |
| positive regulation of cholesterol efflux |
| intracellular sterol transport |
| high-density lipoprotein particle remodeling |
| positive regulation of steroid biosynthetic process |
| cholesterol transfer activity |
| amyloid precursor protein metabolic process |
| negative regulation of lipid storage |
| positive regulation of amyloid precursor protein catabolic process |
| cholesterol efflux |
| positive regulation of cholesterol transport |
| regulation of cholesterol efflux |
| positive regulation of sterol transport |
| positive regulation of alcohol biosynthetic process |
| regulation of amyloid-beta formation |
| positive regulation of steroid metabolic process |
| protein-lipid complex remodeling |
| plasma lipoprotein particle remodeling |
| protein-containing complex remodeling |
| cellular response to lipoprotein particle stimulus |
| regulation of macrophage derived foam cell differentiation |
| regulation of amyloid precursor protein catabolic process |
| intracellular lipid transport |
| ADP binding |
| toxin transport |
| negative regulation of lipid localization |
| regulation of sterol biosynthetic process |
| regulation of cholesterol biosynthetic process |
| plasma lipoprotein particle organization |
| regulation of cholesterol transport |
| regulation of lipid storage |
| regulation of sterol transport |
| protein-lipid complex subunit organization |
| cholesterol binding |
| ATPase-coupled transmembrane transporter activity |
| cholesterol transport |
| regulation of cholesterol metabolic process |
| anion homeostasis |
| positive regulation of lipid transport |
| sterol transport |
| carbohydrate derivative transport |
| regulation of plasma lipoprotein particle levels |
| regulation of alcohol biosynthetic process |
| cholesterol homeostasis |
| positive regulation of lipid biosynthetic process |
| sterol homeostasis |
| positive regulation of lipid localization |
| regulation of steroid biosynthetic process |
| phospholipid transport |
| phospholipid binding |
| regulation of lipid transport |
| regulation of steroid metabolic process |
| recycling endosome |
| cholesterol metabolic process |
| organophosphate ester transport |
| secondary alcohol metabolic process |
| lipid homeostasis |
| sterol metabolic process |
| regulation of lipid localization |
| positive regulation of small molecule metabolic process |
| organic hydroxy compound transport |
| positive regulation of lipid metabolic process |
| positive regulation of cellular amide metabolic process |
| protein dimerization activity |
| regulation of lipid biosynthetic process |
| ATPase activity |
| steroid metabolic process |
| endosome |
| positive regulation of protein secretion |
| positive regulation of peptide secretion |
| lipid transport |
| alcohol metabolic process |
| lipid localization |
| extracellular structure organization |
| external side of plasma membrane |
| regulation of lipid metabolic process |
| regulation of cellular amide metabolic process |
| positive regulation of secretion by cell |
| positive regulation of protein transport |
| regulation of small molecule metabolic process |
| positive regulation of secretion |
| organic hydroxy compound metabolic process |
| organic anion transport |
| positive regulation of establishment of protein localization |
| regulation of protein secretion |
| protein heterodimerization activity |
| regulation of peptide secretion |
| detection of chemical stimulus |
| anion transport |
| Golgi membrane |
| detection of stimulus |
| regulation of protein transport |
| negative regulation of cell differentiation |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| ion homeostasis |
| regulation of secretion |
| response to lipid |
| protein homodimerization activity |
| response to hormone |
| endoplasmic reticulum membrane |
| negative regulation of developmental process |
| ion transmembrane transport |
| Golgi apparatus |
| positive regulation of transport |
| regulation of protein localization |
| chemical homeostasis |
| lipid metabolic process |
| mitochondrion |
| transmembrane transport |
| ion transport |
| response to endogenous stimulus |
| ATP binding |
| protein transport |
| intracellular transport |
| peptide transport |
| amide transport |
| establishment of protein localization |
| homeostatic process |
| positive regulation of protein metabolic process |
| small molecule metabolic process |
| regulation of cell differentiation |
| establishment of localization in cell |
| nitrogen compound transport |
| protein-containing complex subunit organization |
| regulation of transport |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Cerivastatin 0.15μM R05 exp226 | -2.8 |
| BH1 1μM R04 exp169 | 1.79 |
| Thimerosal 0.85μM R08 exp529 | 1.97 |
| Vemurafenib 6.6μM R02 exp89 | 2.17 |
| UM0125461 0.74μM R02 exp84 | 2.81 |
| Vemurafenib 6.6μM R08 exp434 | 3.51 |
| Tubacin 1.6μM R07 exp416 | 4.11 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| NR1H2 | 0.427 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 16/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 1/28 |
| blood | 2/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 1/75 |
| lymphocyte | 1/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 1/16 |
| plasma cell | 1/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 1/22 |
| urinary tract | 1/29 |
| uterus | 1/5 |
Essentiality in NALM6
- Essentiality Rank: 17302
- Expression level (log2 read counts): 6.79
Expression Distribution
ABCG1 Expression in NALM6 Cells: 6.79
