ABHD17C [The Human Chemical-Genetic Interaction Map Project]

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======= ABHD17C =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ABHD17C
  * **<color #00a2e8>Official Name</color>**: abhydrolase domain containing 17C, depalmitoylase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=58489|58489]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6PCB6|Q6PCB6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ABHD17C&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ABHD17C|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617944|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards NRAS and DLG4/PSD95. {ECO:0000269|PubMed:26701913}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Abhydrolase 5|
|Abhydrolase 6|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of protein localization to microtubule|
|negative regulation of protein localization to microtubule|
|protein depalmitoylation|
|macromolecule depalmitoylation|
|palmitoyl-(protein) hydrolase activity|
|positive regulation of protein localization to endosome|
|regulation of protein localization to endosome|
|lipoprotein catabolic process|
|protein palmitoylation|
|protein deacylation|
|macromolecule deacylation|
|recycling endosome membrane|
|protein lipidation|
|lipoprotein biosynthetic process|
|regulation of postsynapse organization|
|negative regulation of cellular protein localization|
|lipoprotein metabolic process|
|dendritic spine|
|protein acylation|
|postsynaptic membrane|
|regulation of synapse organization|
|regulation of synapse structure or activity|
|postsynaptic density|
|positive regulation of cellular protein localization|
|glutamatergic synapse|
|regulation of cellular protein localization|
|cell junction|
|protein catabolic process|
|regulation of cellular localization|
|regulation of protein localization|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|organonitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|organic substance catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|-1.84|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|1.76|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|1.85|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|2.06|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9412
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ABHD17C Expression in NALM6 Cells: 3.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>