ABHD17C

Entrez Summary: N/A
UniProt Summary: Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards NRAS and DLG4/PSD95. {ECO:0000269|PubMed:26701913}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Abhydrolase 5
Abhydrolase 6

regulation of protein localization to microtubule
negative regulation of protein localization to microtubule
protein depalmitoylation
macromolecule depalmitoylation
palmitoyl-(protein) hydrolase activity
positive regulation of protein localization to endosome
regulation of protein localization to endosome
lipoprotein catabolic process
protein palmitoylation
protein deacylation
macromolecule deacylation
recycling endosome membrane
protein lipidation
lipoprotein biosynthetic process
regulation of postsynapse organization
negative regulation of cellular protein localization
lipoprotein metabolic process
dendritic spine
protein acylation
postsynaptic membrane
regulation of synapse organization
regulation of synapse structure or activity
postsynaptic density
positive regulation of cellular protein localization
glutamatergic synapse
regulation of cellular protein localization
cell junction
protein catabolic process
regulation of cellular localization
regulation of protein localization
macromolecule catabolic process
organonitrogen compound catabolic process
organonitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
organic substance catabolic process