ABHD3

Entrez Summary: N/A
UniProt Summary: Phospholipase that may play a role in phospholipids remodeling. May selectively cleave myristate (C14)-containing phosphatidylcholines through its predominant phospholipase 1 activity, cleaving preferentially acyl groups in sn1 position. In parallel, may have a minor phospholipase 2 activity acting on acyl groups in position sn2. In addition to (C14)-containing phosphatidylcholines, may also act on other medium-chain- containing and oxidatively truncated phospholipids. {ECO:0000269|PubMed:21926997}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

short-chain carboxylesterase activity
medium-chain fatty acid catabolic process
1-acyl-2-lysophosphatidylserine acylhydrolase activity
medium-chain fatty acid biosynthetic process
phosphatidylserine 1-acylhydrolase activity
phospholipase A1 activity
acylglycerol lipase activity
medium-chain fatty acid metabolic process
lipase activity
phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)
phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)
phospholipase A2 activity
phosphatidylcholine biosynthetic process
phosphatidylcholine metabolic process
fatty acid catabolic process
monocarboxylic acid catabolic process
fatty acid biosynthetic process
monocarboxylic acid biosynthetic process
ammonium ion metabolic process
cellular lipid catabolic process
glycerophospholipid biosynthetic process
glycerolipid biosynthetic process
phospholipid biosynthetic process
organic acid catabolic process
carboxylic acid catabolic process
lipid catabolic process
carboxylic acid biosynthetic process
organic acid biosynthetic process
glycerophospholipid metabolic process
fatty acid metabolic process
phospholipid metabolic process
glycerolipid metabolic process
small molecule catabolic process
cellular component
monocarboxylic acid metabolic process
organophosphate biosynthetic process
lipid biosynthetic process
small molecule biosynthetic process
organophosphate metabolic process
carboxylic acid metabolic process