ABI2 [The Human Chemical-Genetic Interaction Map Project]

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======= ABI2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ABI2
  * **<color #00a2e8>Official Name</color>**: abl interactor 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10152|10152]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NYB9|Q9NYB9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ABI2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ABI2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606442|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). {ECO:0000250|UniProtKB:P62484, ECO:0000269|PubMed:10498863, ECO:0000269|PubMed:7590236, ECO:0000269|PubMed:8649853}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SH3 2|
|Abi HHR|
|SH3 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|lens fiber cell morphogenesis|
|positive regulation of Arp2/3 complex-mediated actin nucleation|
|SCAR complex|
|cytoskeletal adaptor activity|
|lens fiber cell development|
|positive regulation of actin nucleation|
|regulation of Arp2/3 complex-mediated actin nucleation|
|filopodium tip|
|proline-rich region binding|
|Rac protein signal transduction|
|lens morphogenesis in camera-type eye|
|lens fiber cell differentiation|
|regulation of actin nucleation|
|regulation of dendritic spine morphogenesis|
|actin polymerization or depolymerization|
|Rac GTPase binding|
|adherens junction|
|regulation of dendritic spine development|
|lens development in camera-type eye|
|regulation of dendrite morphogenesis|
|positive regulation of actin filament polymerization|
|kinase binding|
|regulation of postsynapse organization|
|camera-type eye morphogenesis|
|positive regulation of protein polymerization|
|SH3 domain binding|
|peptidyl-tyrosine phosphorylation|
|peptidyl-tyrosine modification|
|eye morphogenesis|
|dendritic spine|
|regulation of dendrite development|
|regulation of actin filament polymerization|
|lamellipodium|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|epithelial cell development|
|positive regulation of supramolecular fiber organization|
|regulation of synapse organization|
|positive regulation of cytoskeleton organization|
|regulation of protein polymerization|
|regulation of synapse structure or activity|
|actin filament organization|
|Ras protein signal transduction|
|positive regulation of protein complex assembly|
|sensory organ morphogenesis|
|regulation of actin filament organization|
|ubiquitin protein ligase binding|
|regulation of cell morphogenesis involved in differentiation|
|camera-type eye development|
|small GTPase mediated signal transduction|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|eye development|
|visual system development|
|cytoskeleton|
|sensory system development|
|regulation of cellular component size|
|regulation of actin filament-based process|
|regulation of protein complex assembly|
|supramolecular fiber organization|
|regulation of cell morphogenesis|
|actin cytoskeleton organization|
|regulation of neuron projection development|
|regulation of anatomical structure size|
|positive regulation of cellular component biogenesis|
|regulation of cytoskeleton organization|
|sensory organ development|
|cell morphogenesis involved in differentiation|
|actin filament-based process|
|positive regulation of organelle organization|
|regulation of neuron differentiation|
|epithelial cell differentiation|
|regulation of plasma membrane bounded cell projection organization|
|viral process|
|regulation of cell projection organization|
|cell morphogenesis|
|symbiotic process|
|regulation of neurogenesis|
|interspecies interaction between organisms|
|cellular component morphogenesis|
|peptidyl-amino acid modification|
|regulation of nervous system development|
|regulation of cell development|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|cell migration|
|protein phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell motility|
|localization of cell|
|cytoskeleton organization|
|epithelium development|
|positive regulation of cellular component organization|
|phosphorylation|
|regulation of organelle organization|
|locomotion|
|DNA binding|
|generation of neurons|
|movement of cell or subcellular component|
|neurogenesis|
|cell development|
|intracellular signal transduction|
|tissue development|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|-1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16352
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ABI2 Expression in NALM6 Cells: 6.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>