ABI2

Entrez Summary: N/A
UniProt Summary: May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). {ECO:0000250|UniProtKB:P62484, ECO:0000269|PubMed:10498863, ECO:0000269|PubMed:7590236, ECO:0000269|PubMed:8649853}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

lens fiber cell morphogenesis
positive regulation of Arp2/3 complex-mediated actin nucleation
SCAR complex
cytoskeletal adaptor activity
lens fiber cell development
positive regulation of actin nucleation
regulation of Arp2/3 complex-mediated actin nucleation
filopodium tip
proline-rich region binding
Rac protein signal transduction
lens morphogenesis in camera-type eye
lens fiber cell differentiation
regulation of actin nucleation
regulation of dendritic spine morphogenesis
actin polymerization or depolymerization
Rac GTPase binding
adherens junction
regulation of dendritic spine development
lens development in camera-type eye
regulation of dendrite morphogenesis
positive regulation of actin filament polymerization
kinase binding
regulation of postsynapse organization
camera-type eye morphogenesis
positive regulation of protein polymerization
SH3 domain binding
peptidyl-tyrosine phosphorylation
peptidyl-tyrosine modification
eye morphogenesis
dendritic spine
regulation of dendrite development
regulation of actin filament polymerization
lamellipodium
regulation of actin polymerization or depolymerization
regulation of actin filament length
epithelial cell development
positive regulation of supramolecular fiber organization
regulation of synapse organization
positive regulation of cytoskeleton organization
regulation of protein polymerization