ABRA [The Human Chemical-Genetic Interaction Map Project]

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======= ABRA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ABRA
  * **<color #00a2e8>Official Name</color>**: actin binding Rho activating protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=137735|137735]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N0Z2|Q8N0Z2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ABRA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ABRA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609747|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as an activator of serum response factor (SRF)- dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling. {ECO:0000250|UniProtKB:Q8BUZ1}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of Rho protein signal transduction|
|sarcomere|
|positive regulation of Ras protein signal transduction|
|positive regulation of small GTPase mediated signal transduction|
|protein import into nucleus|
|import into nucleus|
|protein import|
|regulation of Rho protein signal transduction|
|protein localization to nucleus|
|actin cytoskeleton|
|regulation of Ras protein signal transduction|
|positive regulation of DNA-binding transcription factor activity|
|nucleocytoplasmic transport|
|nuclear transport|
|actin binding|
|regulation of small GTPase mediated signal transduction|
|regulation of DNA-binding transcription factor activity|
|establishment of protein localization to organelle|
|protein localization to organelle|
|intracellular protein transport|
|positive regulation of intracellular signal transduction|
|positive regulation of transcription by RNA polymerase II|
|protein transport|
|intracellular transport|
|peptide transport|
|positive regulation of transcription, DNA-templated|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|positive regulation of RNA metabolic process|
|positive regulation of molecular function|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|nitrogen compound transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|-2.12|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|-1.93|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|-1.92|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|-1.7|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12757
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ABRA Expression in NALM6 Cells: -1.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>