ABRA

Entrez Summary: N/A
UniProt Summary: Acts as an activator of serum response factor (SRF)- dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling. {ECO:0000250|UniProtKB:Q8BUZ1}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

positive regulation of Rho protein signal transduction
sarcomere
positive regulation of Ras protein signal transduction
positive regulation of small GTPase mediated signal transduction
protein import into nucleus
import into nucleus
protein import
regulation of Rho protein signal transduction
protein localization to nucleus
actin cytoskeleton
regulation of Ras protein signal transduction
positive regulation of DNA-binding transcription factor activity
nucleocytoplasmic transport
nuclear transport
actin binding
regulation of small GTPase mediated signal transduction
regulation of DNA-binding transcription factor activity
establishment of protein localization to organelle
protein localization to organelle
intracellular protein transport
positive regulation of intracellular signal transduction
positive regulation of transcription by RNA polymerase II
protein transport
intracellular transport
peptide transport
positive regulation of transcription, DNA-templated
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
positive regulation of signal transduction
positive regulation of RNA metabolic process
positive regulation of molecular function
positive regulation of cell communication
positive regulation of signaling
regulation of intracellular signal transduction
establishment of localization in cell
nitrogen compound transport