ACADM [The Human Chemical-Genetic Interaction Map Project]

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======= ACADM =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ACADM
  * **<color #00a2e8>Official Name</color>**: acyl-CoA dehydrogenase medium chain
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=34|34]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P11310|P11310]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ACADM&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ACADM|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607008|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the medium-chain specific (C4 to C12 straight chain) acyl-Coenzyme A dehydrogenase. The homotetramer enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Defects in this gene cause medium-chain acyl-CoA dehydrogenase deficiency, a disease characterized by hepatic dysfunction, fasting hypoglycemia, and encephalopathy, which can result in infantile death. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Acyl-CoA dehydrogenase specific for acyl chain lengths of 4 to 16 that catalyzes the initial step of fatty acid beta- oxidation. Utilizes the electron transfer flavoprotein (ETF) as an electron acceptor to transfer electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). {ECO:0000269|PubMed:25416781}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Acyl-CoA dh N|
|Acyl-CoA dh 1|
|Acyl-CoA dh M|
|Acyl-CoA dh 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|medium-chain-acyl-CoA dehydrogenase activity|
|carnitine metabolic process, CoA-linked|
|carnitine biosynthetic process|
|medium-chain fatty acid catabolic process|
|acyl-CoA dehydrogenase activity|
|amino-acid betaine biosynthetic process|
|fatty acid beta-oxidation using acyl-CoA dehydrogenase|
|medium-chain fatty acid metabolic process|
|carnitine metabolic process|
|amino-acid betaine metabolic process|
|cellular modified amino acid biosynthetic process|
|flavin adenine dinucleotide binding|
|fatty acid beta-oxidation|
|fatty acid oxidation|
|lipid oxidation|
|fatty acid catabolic process|
|mitochondrial membrane|
|monocarboxylic acid catabolic process|
|ammonium ion metabolic process|
|cellular lipid catabolic process|
|cellular modified amino acid metabolic process|
|lipid modification|
|organic acid catabolic process|
|carboxylic acid catabolic process|
|axon|
|lipid catabolic process|
|fatty acid metabolic process|
|mitochondrial matrix|
|regulation of lipid metabolic process|
|nuclear speck|
|small molecule catabolic process|
|monocarboxylic acid metabolic process|
|carboxylic acid metabolic process|
|cellular lipid metabolic process|
|oxidation-reduction process|
|oxoacid metabolic process|
|organic acid metabolic process|
|identical protein binding|
|lipid metabolic process|
|mitochondrion|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp486|Heregulin-B 44ng/ml R08 exp486]]|1.93|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.451|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10899
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.17 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ACADM Expression in NALM6 Cells: 6.17'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>