ACADM

Entrez Summary: This gene encodes the medium-chain specific (C4 to C12 straight chain) acyl-Coenzyme A dehydrogenase. The homotetramer enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Defects in this gene cause medium-chain acyl-CoA dehydrogenase deficiency, a disease characterized by hepatic dysfunction, fasting hypoglycemia, and encephalopathy, which can result in infantile death. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
UniProt Summary: Acyl-CoA dehydrogenase specific for acyl chain lengths of 4 to 16 that catalyzes the initial step of fatty acid beta- oxidation. Utilizes the electron transfer flavoprotein (ETF) as an electron acceptor to transfer electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). {ECO:0000269|PubMed:25416781}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

medium-chain-acyl-CoA dehydrogenase activity
carnitine metabolic process, CoA-linked
carnitine biosynthetic process
medium-chain fatty acid catabolic process
acyl-CoA dehydrogenase activity
amino-acid betaine biosynthetic process
fatty acid beta-oxidation using acyl-CoA dehydrogenase
medium-chain fatty acid metabolic process
carnitine metabolic process
amino-acid betaine metabolic process
cellular modified amino acid biosynthetic process
flavin adenine dinucleotide binding
fatty acid beta-oxidation
fatty acid oxidation
lipid oxidation
fatty acid catabolic process
mitochondrial membrane
monocarboxylic acid catabolic process
ammonium ion metabolic process
cellular lipid catabolic process
cellular modified amino acid metabolic process
lipid modification
organic acid catabolic process
carboxylic acid catabolic process
axon
lipid catabolic process
fatty acid metabolic process
mitochondrial matrix
regulation of lipid metabolic process
nuclear speck
small molecule catabolic process
monocarboxylic acid metabolic process
carboxylic acid metabolic process
cellular lipid metabolic process
oxidation-reduction process
oxoacid metabolic process
organic acid metabolic process
identical protein binding
lipid metabolic process
mitochondrion