ACER2

Gene Information

Official Symbol: ACER2
Official Name: alkaline ceramidase 2
Aliases and Previous Symbols: N/A
Entrez ID: 340485
UniProt: Q5QJU3
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. Unsaturated long-chain ceramides are the best substrates, saturated long-chain ceramides and unsaturated very long-chain ceramides are good substrates, whereas saturated very long-chain ceramides and short-chain ceramides were poor substrates. The substrate preference is D-erythro-C(18:1)-, C(20:1)-, C(20:4)-ceramide > D-erythro-C(16:0)-, C(18:0), C(20:0)- ceramide > D-erythro-C(24:1)-ceramide > D-erythro-C(12:0)- ceramide, D-erythro-C(14:0)-ceramides > D-erythro-C(24:0)-ceramide > D-erythro-C(6:0)-ceramide. Inhibits the maturation of protein glycosylation in the Golgi complex, including that of integrin beta-1 (ITGB1) and of LAMP1, by increasing the levels of sphingosine. Inhibits cell adhesion by reducing the level of ITGB1 in the cell surface. May have a role in cell proliferation and apoptosis that seems to depend on the balance between sphingosine and sphingosine-1-phosphate. {ECO:0000269|PubMed:16940153, ECO:0000269|PubMed:18945876, ECO:0000269|PubMed:20089856}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 15912
Expression level (log2 read counts): 0.94

Expression Distribution

negative regulation of protein glycosylation in Golgi
dihydroceramidase activity
regulation of protein glycosylation in Golgi
negative regulation of protein glycosylation
ceramidase activity
N-acylsphingosine amidohydrolase activity
negative regulation of cell adhesion mediated by integrin
sphingosine biosynthetic process
sphingoid biosynthetic process
sphingosine metabolic process
negative regulation of glycoprotein biosynthetic process
regulation of protein glycosylation
sphingoid metabolic process
negative regulation of glycoprotein metabolic process
diol biosynthetic process
ceramide catabolic process
diol metabolic process
sphingolipid catabolic process
membrane lipid catabolic process
negative regulation of cell-matrix adhesion
regulation of glycoprotein biosynthetic process
regulation of glycoprotein metabolic process
regulation of cell adhesion mediated by integrin
polyol biosynthetic process
negative regulation of cell-substrate adhesion
integral component of Golgi membrane
DNA damage response, signal transduction by p53 class mediator
ceramide metabolic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
sphingolipid biosynthetic process
signal transduction in response to DNA damage
response to retinoic acid
polyol metabolic process
alcohol biosynthetic process
regulation of cell-matrix adhesion
signal transduction by p53 class mediator
membrane lipid biosynthetic process
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of cysteine-type endopeptidase activity
sphingolipid metabolic process