ACER3

Entrez Summary: N/A
UniProt Summary: Hydrolyzes only phytoceramide into phytosphingosine and free fatty acid. Does not have reverse activity.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

phytoceramidase activity
phytosphingosine metabolic process
phytosphingosine biosynthetic process
dihydroceramidase activity
ceramidase activity
N-acylsphingosine amidohydrolase activity
sphingosine biosynthetic process
sphingoid biosynthetic process
sphingosine metabolic process
sphingoid metabolic process
diol biosynthetic process
ceramide catabolic process
diol metabolic process
sphingolipid catabolic process
membrane lipid catabolic process
polyol biosynthetic process
integral component of Golgi membrane
ceramide metabolic process
sphingolipid biosynthetic process
myelination
integral component of endoplasmic reticulum membrane
axon ensheathment
ensheathment of neurons
polyol metabolic process
alcohol biosynthetic process
membrane lipid biosynthetic process
sphingolipid metabolic process
organic hydroxy compound biosynthetic process
ammonium ion metabolic process
cellular lipid catabolic process
membrane lipid metabolic process
lipid catabolic process
alcohol metabolic process
organic hydroxy compound metabolic process
inflammatory response
lipid biosynthetic process
small molecule biosynthetic process
calcium ion binding
cellular amide metabolic process
zinc ion binding