ACO2 [The Human Chemical-Genetic Interaction Map Project]

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======= ACO2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ACO2
  * **<color #00a2e8>Official Name</color>**: aconitase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=50|50]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99798|Q99798]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ACO2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ACO2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/100850|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the isomerization of citrate to isocitrate via cis-aconitate. {ECO:0000250|UniProtKB:P16276}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Aconitase|
|Aconitase C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|3 iron, 4 sulfur cluster binding|
|aconitate hydratase activity|
|citrate metabolic process|
|response to isolation stress|
|isocitrate metabolic process|
|tricarboxylic acid metabolic process|
|tricarboxylic acid cycle|
|4 iron, 4 sulfur cluster binding|
|aerobic respiration|
|antibiotic metabolic process|
|liver development|
|secondary alcohol metabolic process|
|hepaticobiliary system development|
|iron ion binding|
|cellular respiration|
|energy derivation by oxidation of organic compounds|
|alcohol metabolic process|
|mitochondrial matrix|
|gland development|
|generation of precursor metabolites and energy|
|organic hydroxy compound metabolic process|
|drug metabolic process|
|carboxylic acid metabolic process|
|oxidation-reduction process|
|oxoacid metabolic process|
|organic acid metabolic process|
|mitochondrion|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|-2.36|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|-2.13|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-1.75|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-1.73|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-1.72|
|[[:results:exp16|DABN 2μM R00 exp16]]|1.7|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|1.71|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|1.72|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|1.85|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|1.89|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|2.08|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|2.1|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|2.18|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|2.37|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|2.38|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|2.42|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|2.43|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|3.13|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.552|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.414|
|[[:human genes:s:supt6h|SUPT6H]]|0.413|
|[[:human genes:d:dnm2|DNM2]]|0.406|
|[[:human genes:c:cope|COPE]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 151/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|12/28|
|blood|5/28|
|bone|2/26|
|breast|15/33|
|central nervous system|2/56|
|cervix|1/4|
|colorectal|6/17|
|esophagus|3/13|
|fibroblast|0/1|
|gastric|6/16|
|kidney|3/21|
|liver|3/20|
|lung|16/75|
|lymphocyte|1/16|
|ovary|7/26|
|pancreas|8/24|
|peripheral nervous system|3/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|3/22|
|urinary tract|4/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1438
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ACO2 Expression in NALM6 Cells: 7.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>