ACO2

Entrez Summary: The protein encoded by this gene belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification. [provided by RefSeq, Jul 2008].
UniProt Summary: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate. {ECO:0000250|UniProtKB:P16276}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Hippuristanol 0.12μM R08 exp488	-2.36
Hippuristanol 0.12μM R08 exp489 no dilution day6	-2.13
Fluvastatin 2.2μM R06 exp282	-1.75
CoCl2 18μM R07 exp346	-1.73
ABT-702 5μM plus CoCl2 18μM R07 exp320	-1.72
DABN 2μM R00 exp16	1.7
CCCP 0.1μM R00 exp10	1.71
GSK2606414 1μM R05 exp236	1.72
Wortmannin 5μM R00 exp38	1.85
Epothilone-B 0.0015μM R05 exp231	1.89
Doxycycline 10μM R00 exp18	2.08
Chloramphenicol 2μM R00 exp12	2.1
UM0131023 0.05μM R05 exp248	2.18
BI-2536 0.001μM R01 exp41	2.37
2-Methoxyestradiol 0.2μM R01 exp40	2.38
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	2.42
Nifuroxazide 5μM R03 exp102	2.43
2-Deoxy-D-glucose 800μM R05 exp214	3.13

Global Fraction of Cell Lines Where Essential: 151/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	12/28
blood	5/28
bone	2/26
breast	15/33
central nervous system	2/56
cervix	1/4
colorectal	6/17
esophagus	3/13
fibroblast	0/1
gastric	6/16
kidney	3/21
liver	3/20
lung	16/75
lymphocyte	1/16
ovary	7/26
pancreas	8/24
peripheral nervous system	3/16
plasma cell	0/15
prostate	0/1
skin	2/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	3/22
urinary tract	4/29
uterus	3/5

Expression Distribution

Aconitase
Aconitase C

3 iron, 4 sulfur cluster binding
aconitate hydratase activity
citrate metabolic process
response to isolation stress
isocitrate metabolic process
tricarboxylic acid metabolic process
tricarboxylic acid cycle
4 iron, 4 sulfur cluster binding
aerobic respiration
antibiotic metabolic process
liver development
secondary alcohol metabolic process
hepaticobiliary system development
iron ion binding
cellular respiration
energy derivation by oxidation of organic compounds
alcohol metabolic process
mitochondrial matrix
gland development
generation of precursor metabolites and energy
organic hydroxy compound metabolic process
drug metabolic process
carboxylic acid metabolic process
oxidation-reduction process
oxoacid metabolic process
organic acid metabolic process
mitochondrion
small molecule metabolic process