ACOT4

Entrez Summary: N/A
UniProt Summary: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (By similarity). Succinyl-CoA thioesterase that also hydrolyzes long chain saturated and unsaturated monocarboxylic acyl-CoAs. {ECO:0000250, ECO:0000269|PubMed:16940157}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

saturated monocarboxylic acid metabolic process
unsaturated monocarboxylic acid metabolic process
succinyl-CoA hydrolase activity
butyrate metabolic process
succinyl-CoA metabolic process
myristoyl-CoA hydrolase activity
palmitoyl-CoA hydrolase activity
acyl-CoA hydrolase activity
short-chain fatty acid metabolic process
dicarboxylic acid catabolic process
very long-chain fatty acid metabolic process
carboxylic ester hydrolase activity
peroxisomal matrix
establishment of protein localization to peroxisome
protein localization to peroxisome
protein targeting to peroxisome
peroxisomal transport
peroxisome organization
acyl-CoA metabolic process
dicarboxylic acid metabolic process
thioester metabolic process
peroxisome
long-chain fatty acid metabolic process
fatty acid biosynthetic process
ribonucleoside bisphosphate metabolic process
purine nucleoside bisphosphate metabolic process
nucleoside bisphosphate metabolic process
monocarboxylic acid biosynthetic process
coenzyme metabolic process
carboxylic acid catabolic process
organic acid catabolic process
carboxylic acid biosynthetic process
organic acid biosynthetic process
purine ribonucleotide metabolic process
fatty acid metabolic process
ribonucleotide metabolic process
purine nucleotide metabolic process
ribose phosphate metabolic process
protein targeting
sulfur compound metabolic process