ACOX1

Entrez Summary: The protein encoded by this gene is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. It donates electrons directly to molecular oxygen, thereby producing hydrogen peroxide. Defects in this gene result in pseudoneonatal adrenoleukodystrophy, a disease that is characterized by accumulation of very long chain fatty acids. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 3/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	1/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	2/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ACOX
Acyl-CoA dh M

palmitoyl-CoA oxidase activity
acyl-CoA oxidase activity
alpha-linolenic acid metabolic process
fatty acid beta-oxidation using acyl-CoA oxidase
fatty acid binding
very long-chain fatty acid metabolic process
FAD binding
prostanoid metabolic process
prostaglandin metabolic process
peroxisomal matrix
flavin adenine dinucleotide binding
peroxisomal membrane
fatty acid beta-oxidation
protein targeting to peroxisome
protein localization to peroxisome
establishment of protein localization to peroxisome
peroxisomal transport
fatty acid oxidation
lipid oxidation
peroxisome organization
PDZ domain binding
fatty acid catabolic process
protein N-terminus binding
unsaturated fatty acid metabolic process
peroxisome
icosanoid metabolic process
long-chain fatty acid metabolic process
monocarboxylic acid catabolic process
lipid homeostasis
fatty acid derivative metabolic process
cellular lipid catabolic process
lipid modification
carboxylic acid catabolic process
organic acid catabolic process
lipid catabolic process
fatty acid metabolic process
protein targeting
regulation of lipid metabolic process
generation of precursor metabolites and energy
establishment of protein localization to organelle