ACP5

Gene Information

Official Symbol: ACP5
Official Name: acid phosphatase 5, tartrate resistant
Aliases and Previous Symbols: N/A
Entrez ID: 54
UniProt: P13686
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes an iron containing glycoprotein which catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate. [provided by RefSeq, Aug 2008].
UniProt Summary: Involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 5373
Expression level (log2 read counts): -2.79

Expression Distribution

Screen	Score
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	-1.77
Cerivastatin 0.15μM R05 exp226	1.76

Metallophos
Metallophos 2

negative regulation of superoxide anion generation
riboflavin metabolic process
flavin-containing compound metabolic process
acid phosphatase activity
ferric iron binding
negative regulation of nitric oxide biosynthetic process
negative regulation of nitric oxide metabolic process
negative regulation of interleukin-12 production
regulation of superoxide anion generation
bone resorption
ferrous iron binding
negative regulation of interleukin-1 beta production
negative regulation of reactive oxygen species biosynthetic process
negative regulation of interleukin-1 production
regulation of superoxide metabolic process
bone remodeling
regulation of interleukin-12 production
negative regulation of reactive oxygen species metabolic process
regulation of nitric oxide biosynthetic process
negative regulation of tumor necrosis factor production
negative regulation of tumor necrosis factor superfamily cytokine production
regulation of interleukin-1 beta production
regulation of reactive oxygen species biosynthetic process
water-soluble vitamin metabolic process
defense response to Gram-positive bacterium
regulation of interleukin-1 production
tissue remodeling
bone morphogenesis
vitamin metabolic process
negative regulation of inflammatory response
regulation of tumor necrosis factor production
regulation of tumor necrosis factor superfamily cytokine production
regulation of reactive oxygen species metabolic process
tissue homeostasis
bone development
negative regulation of defense response
skeletal system morphogenesis
lysosome
ossification
negative regulation of cytokine production