ACPT

Gene Information

Official Symbol: ACP4
Official Name: acid phosphatase 4
Aliases and Previous Symbols: N/A
Entrez ID: 93650
UniProt: Q9BZG2
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: Acid phosphatases are enzymes capable of hydrolyzing orthophosphoric acid esters in an acid medium. This gene is up-regulated by androgens and is down-regulated by estrogens in the prostate cancer cell line. This gene exhibits a lower level of expression in testicular cancer tissues than in normal tissues. The protein encoded by this gene has structural similarity to prostatic and lysosomal acid phosphatases. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008].
UniProt Summary: May dephosphorylate receptor tyrosine-protein kinase ERBB4 and inhibits its ligand-induced proteolytic cleavage (PubMed:15219672). May play a role in odontogenesis (PubMed:27843125). {ECO:0000269|PubMed:15219672, ECO:0000269|PubMed:27843125}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 7627
Expression level (log2 read counts): -0.18

Expression Distribution

negative regulation of ERBB4 signaling pathway
peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity
acid phosphatase activity
negative regulation of protein maturation
negative regulation of protein processing
negative regulation of ERBB signaling pathway
regulation of neuronal synaptic plasticity
receptor tyrosine kinase binding
regulation of protein processing
regulation of protein maturation
regulation of ERBB signaling pathway
protein tyrosine phosphatase activity
peptidyl-tyrosine dephosphorylation
odontogenesis
negative regulation of neuron projection development
negative regulation of cell projection organization
regulation of synaptic plasticity
postsynaptic membrane
protein dephosphorylation
negative regulation of protein kinase activity
negative regulation of neuron differentiation
negative regulation of kinase activity
negative regulation of transferase activity
negative regulation of neurogenesis
dephosphorylation
negative regulation of nervous system development
negative regulation of cell development
negative regulation of proteolysis
negative regulation of protein phosphorylation
modulation of chemical synaptic transmission
regulation of trans-synaptic signaling
negative regulation of phosphorylation
regulation of neuron projection development
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of protein modification process
regulation of neuron differentiation
regulation of plasma membrane bounded cell projection organization
negative regulation of cellular component organization
regulation of cell projection organization