ACR

Entrez Summary: N/A
UniProt Summary: Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

acrosome matrix dispersal
amidase activity
acrosomal matrix
fucose binding
penetration of zona pellucida
Golgi-associated vesicle
mannose binding
acrosome reaction
binding of sperm to zona pellucida
activation of adenylate cyclase activity
sperm-egg recognition
copper ion binding
drug binding
cell-cell recognition
protease binding
single fertilization
serine-type endopeptidase activity
fertilization
multi-multicellular organism process
cell recognition
response to steroid hormone
proteolysis involved in cellular protein catabolic process
protein-containing complex
cellular protein catabolic process
protein catabolic process
multicellular organismal reproductive process
sexual reproduction
zinc ion binding
multicellular organism reproduction
response to lipid
cellular macromolecule catabolic process
response to hormone
response to organic cyclic compound
multi-organism reproductive process
macromolecule catabolic process
organonitrogen compound catabolic process
proteolysis
reproductive process
reproduction
DNA binding