ACSL1 [The Human Chemical-Genetic Interaction Map Project]

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======= ACSL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ACSL1
  * **<color #00a2e8>Official Name</color>**: acyl-CoA synthetase long chain family member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2180|2180]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P33121|P33121]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ACSL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ACSL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/152425|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and linoleate.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|AMP-binding|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|response to oleic acid|
|adiponectin-activated signaling pathway|
|decanoate-CoA ligase activity|
|long-chain fatty acid import into cell|
|lipid import into cell|
|xenobiotic catabolic process|
|alpha-linolenic acid metabolic process|
|long-chain fatty acid-CoA ligase activity|
|acyl-CoA ligase activity|
|linoleic acid metabolic process|
|long-chain fatty-acyl-CoA biosynthetic process|
|triglyceride biosynthetic process|
|acylglycerol biosynthetic process|
|neutral lipid biosynthetic process|
|long-chain fatty-acyl-CoA metabolic process|
|fatty-acyl-CoA biosynthetic process|
|fatty-acyl-CoA metabolic process|
|thioester biosynthetic process|
|acyl-CoA biosynthetic process|
|peroxisomal membrane|
|long-chain fatty acid transport|
|purine nucleoside bisphosphate biosynthetic process|
|nucleoside bisphosphate biosynthetic process|
|ribonucleoside bisphosphate biosynthetic process|
|fatty acid transport|
|triglyceride metabolic process|
|response to fatty acid|
|fatty acid derivative biosynthetic process|
|acyl-CoA metabolic process|
|thioester metabolic process|
|positive regulation of cold-induced thermogenesis|
|acylglycerol metabolic process|
|neutral lipid metabolic process|
|unsaturated fatty acid metabolic process|
|long-chain fatty acid metabolic process|
|xenobiotic metabolic process|
|nucleoside bisphosphate metabolic process|
|ribonucleoside bisphosphate metabolic process|
|purine nucleoside bisphosphate metabolic process|
|monocarboxylic acid transport|
|coenzyme biosynthetic process|
|regulation of cold-induced thermogenesis|
|purine ribonucleotide biosynthetic process|
|purine nucleotide biosynthetic process|
|ribonucleotide biosynthetic process|
|mitochondrial outer membrane|
|fatty acid derivative metabolic process|
|ribose phosphate biosynthetic process|
|hormone-mediated signaling pathway|
|purine-containing compound biosynthetic process|
|sulfur compound biosynthetic process|
|cellular response to xenobiotic stimulus|
|cofactor biosynthetic process|
|response to nutrient|
|glycerolipid biosynthetic process|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|coenzyme metabolic process|
|carboxylic acid transport|
|organic acid transport|
|lipid transport|
|response to xenobiotic stimulus|
|purine ribonucleotide metabolic process|
|lipid localization|
|fatty acid metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|positive regulation of protein serine/threonine kinase activity|
|response to acid chemical|
|sulfur compound metabolic process|
|purine-containing compound metabolic process|
|glycerolipid metabolic process|
|regulation of lipid metabolic process|
|cofactor metabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|organic anion transport|
|response to nutrient levels|
|drug metabolic process|
|regulation of protein serine/threonine kinase activity|
|amide biosynthetic process|
|monocarboxylic acid metabolic process|
|response to extracellular stimulus|
|positive regulation of protein kinase activity|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|positive regulation of kinase activity|
|lipid biosynthetic process|
|anion transport|
|cellular response to hormone stimulus|
|carbohydrate derivative biosynthetic process|
|positive regulation of transferase activity|
|cytokine-mediated signaling pathway|
|import into cell|
|cellular amide metabolic process|
|regulation of protein kinase activity|
|response to lipid|
|regulation of kinase activity|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|response to hormone|
|response to organic cyclic compound|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|regulation of transferase activity|
|oxoacid metabolic process|
|cellular response to cytokine stimulus|
|endoplasmic reticulum|
|positive regulation of protein phosphorylation|
|response to drug|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|positive regulation of phosphorylation|
|nucleobase-containing compound biosynthetic process|
|response to cytokine|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|lipid metabolic process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|mitochondrion|
|organic cyclic compound biosynthetic process|
|ion transport|
|organonitrogen compound biosynthetic process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|ATP binding|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|cellular nitrogen compound biosynthetic process|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|regulation of protein modification process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp538|ZLN024 50μM R08 exp538]]|-2.79|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|-2.03|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9403
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.23 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ACSL1 Expression in NALM6 Cells: 4.23'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>