ACSL1
Gene Information
- Official Symbol: ACSL1
- Official Name: acyl-CoA synthetase long chain family member 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 2180
- UniProt: P33121
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and linoleate.
Pfam Domains GO Terms
Pfam Domains
| AMP-binding |
GO Terms
| response to oleic acid |
| adiponectin-activated signaling pathway |
| decanoate-CoA ligase activity |
| long-chain fatty acid import into cell |
| lipid import into cell |
| xenobiotic catabolic process |
| alpha-linolenic acid metabolic process |
| long-chain fatty acid-CoA ligase activity |
| acyl-CoA ligase activity |
| linoleic acid metabolic process |
| long-chain fatty-acyl-CoA biosynthetic process |
| triglyceride biosynthetic process |
| acylglycerol biosynthetic process |
| neutral lipid biosynthetic process |
| long-chain fatty-acyl-CoA metabolic process |
| fatty-acyl-CoA biosynthetic process |
| fatty-acyl-CoA metabolic process |
| thioester biosynthetic process |
| acyl-CoA biosynthetic process |
| peroxisomal membrane |
| long-chain fatty acid transport |
| purine nucleoside bisphosphate biosynthetic process |
| nucleoside bisphosphate biosynthetic process |
| ribonucleoside bisphosphate biosynthetic process |
| fatty acid transport |
| triglyceride metabolic process |
| response to fatty acid |
| fatty acid derivative biosynthetic process |
| acyl-CoA metabolic process |
| thioester metabolic process |
| positive regulation of cold-induced thermogenesis |
| acylglycerol metabolic process |
| neutral lipid metabolic process |
| unsaturated fatty acid metabolic process |
| long-chain fatty acid metabolic process |
| xenobiotic metabolic process |
| nucleoside bisphosphate metabolic process |
| ribonucleoside bisphosphate metabolic process |
| purine nucleoside bisphosphate metabolic process |
| monocarboxylic acid transport |
| coenzyme biosynthetic process |
| regulation of cold-induced thermogenesis |
| purine ribonucleotide biosynthetic process |
| purine nucleotide biosynthetic process |
| ribonucleotide biosynthetic process |
| mitochondrial outer membrane |
| fatty acid derivative metabolic process |
| ribose phosphate biosynthetic process |
| hormone-mediated signaling pathway |
| purine-containing compound biosynthetic process |
| sulfur compound biosynthetic process |
| cellular response to xenobiotic stimulus |
| cofactor biosynthetic process |
| response to nutrient |
| glycerolipid biosynthetic process |
| nucleotide biosynthetic process |
| nucleoside phosphate biosynthetic process |
| coenzyme metabolic process |
| carboxylic acid transport |
| organic acid transport |
| lipid transport |
| response to xenobiotic stimulus |
| purine ribonucleotide metabolic process |
| lipid localization |
| fatty acid metabolic process |
| ribonucleotide metabolic process |
| purine nucleotide metabolic process |
| ribose phosphate metabolic process |
| positive regulation of protein serine/threonine kinase activity |
| response to acid chemical |
| sulfur compound metabolic process |
| purine-containing compound metabolic process |
| glycerolipid metabolic process |
| regulation of lipid metabolic process |
| cofactor metabolic process |
| nucleotide metabolic process |
| nucleoside phosphate metabolic process |
| organic anion transport |
| response to nutrient levels |
| drug metabolic process |
| regulation of protein serine/threonine kinase activity |
| amide biosynthetic process |
| monocarboxylic acid metabolic process |
| response to extracellular stimulus |
| positive regulation of protein kinase activity |
| organophosphate biosynthetic process |
| nucleobase-containing small molecule metabolic process |
| positive regulation of kinase activity |
| lipid biosynthetic process |
| anion transport |
| cellular response to hormone stimulus |
| carbohydrate derivative biosynthetic process |
| positive regulation of transferase activity |
| cytokine-mediated signaling pathway |
| import into cell |
| cellular amide metabolic process |
| regulation of protein kinase activity |
| response to lipid |
| regulation of kinase activity |
| organophosphate metabolic process |
| carboxylic acid metabolic process |
| response to hormone |
| response to organic cyclic compound |
| endoplasmic reticulum membrane |
| cellular lipid metabolic process |
| regulation of transferase activity |
| oxoacid metabolic process |
| cellular response to cytokine stimulus |
| endoplasmic reticulum |
| positive regulation of protein phosphorylation |
| response to drug |
| organic acid metabolic process |
| carbohydrate derivative metabolic process |
| positive regulation of phosphorylation |
| nucleobase-containing compound biosynthetic process |
| response to cytokine |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| lipid metabolic process |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| mitochondrion |
| organic cyclic compound biosynthetic process |
| ion transport |
| organonitrogen compound biosynthetic process |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| ATP binding |
| response to oxygen-containing compound |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| cellular nitrogen compound biosynthetic process |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| small molecule metabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| cellular catabolic process |
| regulation of protein modification process |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| ZLN024 50μM R08 exp538 | -2.79 |
| FBS-Wisent 0.1 R07 exp426 | -2.03 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 9403
- Expression level (log2 read counts): 4.23
Expression Distribution
ACSL1 Expression in NALM6 Cells: 4.23
