ACSL5

Entrez Summary: N/A
UniProt Summary: Acyl-CoA synthetases (ACSL) activate long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage (By similarity). Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids (By similarity). It was suggested that it may also stimulate fatty acid oxidation (By similarity). At the villus tip of the crypt-villus axis of the small intestine may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL. May have a role in the survival of glioma cells. {ECO:0000250, ECO:0000269|PubMed:17681178, ECO:0000269|PubMed:18806831, ECO:0000269|PubMed:19459852}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

decanoate-CoA ligase activity
long-chain fatty acid-CoA ligase activity
acyl-CoA ligase activity
long-chain fatty-acyl-CoA biosynthetic process
long-chain fatty-acyl-CoA metabolic process
fatty-acyl-CoA biosynthetic process
fatty-acyl-CoA metabolic process
thioester biosynthetic process
acyl-CoA biosynthetic process
nucleoside bisphosphate biosynthetic process
purine nucleoside bisphosphate biosynthetic process
ribonucleoside bisphosphate biosynthetic process
fatty acid derivative biosynthetic process
acyl-CoA metabolic process
thioester metabolic process
long-chain fatty acid metabolic process
ribonucleoside bisphosphate metabolic process
purine nucleoside bisphosphate metabolic process
nucleoside bisphosphate metabolic process
coenzyme biosynthetic process
purine ribonucleotide biosynthetic process
purine nucleotide biosynthetic process
ribonucleotide biosynthetic process
mitochondrial outer membrane
fatty acid derivative metabolic process
ribose phosphate biosynthetic process
purine-containing compound biosynthetic process
sulfur compound biosynthetic process
cofactor biosynthetic process
nucleotide biosynthetic process
nucleoside phosphate biosynthetic process
coenzyme metabolic process
purine ribonucleotide metabolic process
fatty acid metabolic process
ribonucleotide metabolic process
purine nucleotide metabolic process
ribose phosphate metabolic process
sulfur compound metabolic process
purine-containing compound metabolic process
cofactor metabolic process