ACSS3

Entrez Summary: N/A
UniProt Summary: Activates acetate so that it can be used for lipid synthesis or for energy generation. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

DUF3448
AMP-binding

acetate-CoA ligase activity
ketone body biosynthetic process
cellular ketone body metabolic process
ketone body metabolic process
fatty acid derivative biosynthetic process
fatty acid derivative metabolic process
mitochondrial matrix
generation of precursor metabolites and energy
drug metabolic process
small molecule biosynthetic process
ATP binding
small molecule metabolic process