ACTA2 [The Human Chemical-Genetic Interaction Map Project]

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======= ACTA2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ACTA2
  * **<color #00a2e8>Official Name</color>**: actin alpha 2, smooth muscle
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=59|59]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P62736|P62736]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ACTA2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ACTA2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/102620|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, integrity, and intercellular signaling. The encoded protein is a smooth muscle actin that is involved in vascular contractility and blood pressure homeostasis. Mutations in this gene cause a variety of vascular diseases, such as thoracic aortic disease, coronary artery disease, stroke, and Moyamoya disease, as well as multisystemic smooth muscle dysfunction syndrome. [provided by RefSeq, Sep 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Actin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|smooth muscle contractile fiber|
|mesenchyme migration|
|glomerular mesangial cell development|
|mesangial cell development|
|glomerular mesangial cell differentiation|
|mesangial cell differentiation|
|glomerular mesangium development|
|pericyte cell differentiation|
|vascular smooth muscle contraction|
|glomerulus vasculature development|
|kidney vasculature development|
|renal system vasculature development|
|epithelial cell differentiation involved in kidney development|
|vasoconstriction|
|negative regulation of blood vessel diameter|
|cell differentiation involved in kidney development|
|mesenchyme morphogenesis|
|glomerulus development|
|smooth muscle contraction|
|filopodium|
|cell body|
|tissue migration|
|nephron development|
|regulation of tube diameter|
|regulation of blood vessel diameter|
|regulation of tube size|
|vascular process in circulatory system|
|lamellipodium|
|regulation of blood pressure|
|epithelial cell development|
|actin cytoskeleton|
|mesenchyme development|
|connective tissue development|
|muscle contraction|
|kidney development|
|response to virus|
|renal system development|
|muscle system process|
|urogenital system development|
|blood circulation|
|circulatory system process|
|protein kinase binding|
|blood vessel development|
|vasculature development|
|regulation of anatomical structure size|
|cardiovascular system development|
|tissue morphogenesis|
|protein-containing complex|
|epithelial cell differentiation|
|circulatory system development|
|animal organ morphogenesis|
|epithelium development|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|ATP binding|
|positive regulation of transcription, DNA-templated|
|extracellular space|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|positive regulation of RNA metabolic process|
|tissue development|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4200
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ACTA2 Expression in NALM6 Cells: 2.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>