ACTA2

Entrez Summary: This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, integrity, and intercellular signaling. The encoded protein is a smooth muscle actin that is involved in vascular contractility and blood pressure homeostasis. Mutations in this gene cause a variety of vascular diseases, such as thoracic aortic disease, coronary artery disease, stroke, and Moyamoya disease, as well as multisystemic smooth muscle dysfunction syndrome. [provided by RefSeq, Sep 2017].
UniProt Summary: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

smooth muscle contractile fiber
mesenchyme migration
glomerular mesangial cell development
mesangial cell development
glomerular mesangial cell differentiation
mesangial cell differentiation
glomerular mesangium development
pericyte cell differentiation
vascular smooth muscle contraction
glomerulus vasculature development
kidney vasculature development
renal system vasculature development
epithelial cell differentiation involved in kidney development
vasoconstriction
negative regulation of blood vessel diameter
cell differentiation involved in kidney development
mesenchyme morphogenesis
glomerulus development
smooth muscle contraction
filopodium
cell body
tissue migration
nephron development
regulation of tube diameter
regulation of blood vessel diameter
regulation of tube size
vascular process in circulatory system
lamellipodium
regulation of blood pressure
epithelial cell development
actin cytoskeleton
mesenchyme development
connective tissue development
muscle contraction
kidney development
response to virus
renal system development
muscle system process
urogenital system development
blood circulation