ACTB [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= ACTB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ACTB
  * **<color #00a2e8>Official Name</color>**: actin beta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=60|60]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P60709|P60709]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ACTB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ACTB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/102630|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, integrity, and intercellular signaling. The encoded protein is a major constituent of the contractile apparatus and one of the two nonmuscle cytoskeletal actins that are ubiquitously expressed. Mutations in this gene cause Baraitser-Winter syndrome 1, which is characterized by intellectual disability with a distinctive facial appearance in human patients. Numerous pseudogenes of this gene have been identified throughout the human genome. [provided by RefSeq, Aug 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Actin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of norepinephrine uptake|
|response to cytochalasin B|
|cellular response to cytochalasin B|
|regulation of norepinephrine uptake|
|structural constituent of postsynaptic actin cytoskeleton|
|cellular response to mycotoxin|
|postsynaptic actin cytoskeleton|
|dense body|
|response to mycotoxin|
|Tat protein binding|
|postsynaptic actin cytoskeleton organization|
|response to platelet aggregation inhibitor|
|postsynaptic cytoskeleton organization|
|nitric-oxide synthase binding|
|NuA4 histone acetyltransferase complex|
|cortical cytoskeleton|
|calyx of Held|
|kinesin binding|
|substantia nigra development|
|synaptic vesicle endocytosis|
|nucleosomal DNA binding|
|presynaptic endocytosis|
|platelet aggregation|
|tau protein binding|
|synaptic vesicle recycling|
|homotypic cell-cell adhesion|
|neural nucleus development|
|positive regulation of gene expression, epigenetic|
|cytoplasmic ribonucleoprotein granule|
|retina homeostasis|
|ATP-dependent chromatin remodeling|
|Schaffer collateral - CA1 synapse|
|midbrain development|
|ephrin receptor signaling pathway|
|postsynapse organization|
|regulation of protein localization to plasma membrane|
|presynapse|
|regulation of cyclin-dependent protein serine/threonine kinase activity|
|RNA polymerase II distal enhancer sequence-specific DNA binding|
|regulation of cyclin-dependent protein kinase activity|
|structural constituent of cytoskeleton|
|negative regulation of protein binding|
|regulation of protein localization to cell periphery|
|synaptic vesicle cycle|
|vesicle-mediated transport in synapse|
|immune response-regulating cell surface receptor signaling pathway involved in phagocytosis|
|Fc-gamma receptor signaling pathway involved in phagocytosis|
|Fc receptor mediated stimulatory signaling pathway|
|platelet activation|
|Fc-gamma receptor signaling pathway|
|blood microparticle|
|vesicle|
|ribonucleoprotein complex|
|chromatin remodeling|
|cell junction assembly|
|negative regulation of binding|
|regulation of protein localization to membrane|
|tissue homeostasis|
|cellular response to toxic substance|
|cell junction organization|
|actin cytoskeleton|
|regulation of protein binding|
|regulation of gene expression, epigenetic|
|nuclear chromatin|
|Fc receptor signaling pathway|
|regulation of transmembrane transporter activity|
|synapse|
|synapse organization|
|regulation of transporter activity|
|protein deubiquitination|
|blood coagulation|
|coagulation|
|axon|
|protein modification by small protein removal|
|hemostasis|
|multicellular organismal homeostasis|
|phagocytosis|
|anatomical structure homeostasis|
|glutamatergic synapse|
|cytoskeleton|
|axonogenesis|
|regulation of binding|
|cellular response to drug|
|axon development|
|focal adhesion|
|cell morphogenesis involved in neuron differentiation|
|immune response-activating cell surface receptor signaling pathway|
|protein kinase binding|
|wound healing|
|neuron projection morphogenesis|
|immune response-regulating cell surface receptor signaling pathway|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|actin cytoskeleton organization|
|regulation of body fluid levels|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|cell-cell adhesion|
|response to toxic substance|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cell part morphogenesis|
|regulation of protein serine/threonine kinase activity|
|regulation of cellular protein localization|
|cellular response to organic cyclic compound|
|endocytosis|
|cell morphogenesis involved in differentiation|
|immune response-activating signal transduction|
|regulation of transmembrane transport|
|actin filament-based process|
|response to wounding|
|protein-containing complex|
|immune response-regulating signaling pathway|
|cellular response to organonitrogen compound|
|activation of immune response|
|cellular response to nitrogen compound|
|neuron projection development|
|import into cell|
|chromatin organization|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|brain development|
|head development|
|regulation of protein kinase activity|
|neuron development|
|cellular component morphogenesis|
|membrane organization|
|positive regulation of immune response|
|regulation of kinase activity|
|regulation of cellular localization|
|response to organic cyclic compound|
|cell adhesion|
|biological adhesion|
|regulation of transferase activity|
|central nervous system development|
|protein modification by small protein conjugation or removal|
|positive regulation of transport|
|response to organonitrogen compound|
|neuron differentiation|
|response to drug|
|regulation of protein localization|
|cellular response to oxygen-containing compound|
|chromosome organization|
|identical protein binding|
|cell activation|
|cell motility|
|localization of cell|
|response to nitrogen compound|
|immune effector process|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|negative regulation of molecular function|
|positive regulation of immune system process|
|regulation of immune response|
|cell projection organization|
|regulation of cell cycle|
|cellular response to endogenous stimulus|
|proteolysis|
|locomotion|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|ATP binding|
|generation of neurons|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|extracellular space|
|neurogenesis|
|homeostatic process|
|cell development|
|regulation of immune system process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|establishment of localization in cell|
|regulation of protein modification process|
|regulation of transport|
|vesicle-mediated transport|
|positive regulation of gene expression|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-3.11|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|-2.3|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|-2.13|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-1.98|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|-1.96|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|-1.89|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-1.84|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-1.74|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.74|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|1.77|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|1.82|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|1.83|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|1.9|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|1.91|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|1.92|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|1.96|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|2|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|2.03|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.13|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.21|
|[[:results:exp73|LJH685 5μM R02 exp73]]|2.23|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|2.61|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.94|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|2.99|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|2.99|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|3.02|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|3.03|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|3.2|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|3.75|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|4.17|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:f:fbxo11|FBXO11]]|0.524|
|[[:human genes:k:khdrbs1|KHDRBS1]]|0.514|
|[[:human genes:z:znf592|ZNF592]]|0.492|
|[[:human genes:i:id3|ID3]]|0.438|
|[[:human genes:c:cbx3|CBX3]]|0.434|
|[[:human genes:b:bap1|BAP1]]|0.427|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.425|
|[[:human genes:m:med13l|MED13L]]|0.422|
|[[:human genes:t:tp53|TP53]]|0.42|
|[[:human genes:p:prkrir|PRKRIR]]|0.42|
|[[:human genes:s:sp3|SP3]]|0.417|
|[[:human genes:s:stip1|STIP1]]|0.407|
|[[:human genes:m:med23|MED23]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 169/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|8/28|
|blood|6/28|
|bone|1/25|
|breast|12/33|
|central nervous system|11/56|
|cervix|2/4|
|colorectal|4/17|
|esophagus|5/13|
|fibroblast|0/1|
|gastric|4/15|
|kidney|5/21|
|liver|9/20|
|lung|15/75|
|lymphocyte|3/14|
|ovary|5/26|
|pancreas|6/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|4/7|
|thyroid|1/2|
|upper aerodigestive|7/22|
|urinary tract|12/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2193
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 11.22 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ACTB Expression in NALM6 Cells: 11.22'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>