ACTB
Gene Information
- Official Symbol: ACTB
- Official Name: actin beta
- Aliases and Previous Symbols: N/A
- Entrez ID: 60
- UniProt: P60709
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, integrity, and intercellular signaling. The encoded protein is a major constituent of the contractile apparatus and one of the two nonmuscle cytoskeletal actins that are ubiquitously expressed. Mutations in this gene cause Baraitser-Winter syndrome 1, which is characterized by intellectual disability with a distinctive facial appearance in human patients. Numerous pseudogenes of this gene have been identified throughout the human genome. [provided by RefSeq, Aug 2017].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Actin |
GO Terms
| positive regulation of norepinephrine uptake |
| response to cytochalasin B |
| cellular response to cytochalasin B |
| regulation of norepinephrine uptake |
| structural constituent of postsynaptic actin cytoskeleton |
| cellular response to mycotoxin |
| postsynaptic actin cytoskeleton |
| dense body |
| response to mycotoxin |
| Tat protein binding |
| postsynaptic actin cytoskeleton organization |
| response to platelet aggregation inhibitor |
| postsynaptic cytoskeleton organization |
| nitric-oxide synthase binding |
| NuA4 histone acetyltransferase complex |
| cortical cytoskeleton |
| calyx of Held |
| kinesin binding |
| substantia nigra development |
| synaptic vesicle endocytosis |
| nucleosomal DNA binding |
| presynaptic endocytosis |
| platelet aggregation |
| tau protein binding |
| synaptic vesicle recycling |
| homotypic cell-cell adhesion |
| neural nucleus development |
| positive regulation of gene expression, epigenetic |
| cytoplasmic ribonucleoprotein granule |
| retina homeostasis |
| ATP-dependent chromatin remodeling |
| Schaffer collateral - CA1 synapse |
| midbrain development |
| ephrin receptor signaling pathway |
| postsynapse organization |
| regulation of protein localization to plasma membrane |
| presynapse |
| regulation of cyclin-dependent protein serine/threonine kinase activity |
| RNA polymerase II distal enhancer sequence-specific DNA binding |
| regulation of cyclin-dependent protein kinase activity |
| structural constituent of cytoskeleton |
| negative regulation of protein binding |
| regulation of protein localization to cell periphery |
| synaptic vesicle cycle |
| vesicle-mediated transport in synapse |
| immune response-regulating cell surface receptor signaling pathway involved in phagocytosis |
| Fc-gamma receptor signaling pathway involved in phagocytosis |
| Fc receptor mediated stimulatory signaling pathway |
| platelet activation |
| Fc-gamma receptor signaling pathway |
| blood microparticle |
| vesicle |
| ribonucleoprotein complex |
| chromatin remodeling |
| cell junction assembly |
| negative regulation of binding |
| regulation of protein localization to membrane |
| tissue homeostasis |
| cellular response to toxic substance |
| cell junction organization |
| actin cytoskeleton |
| regulation of protein binding |
| regulation of gene expression, epigenetic |
| nuclear chromatin |
| Fc receptor signaling pathway |
| regulation of transmembrane transporter activity |
| synapse |
| synapse organization |
| regulation of transporter activity |
| protein deubiquitination |
| blood coagulation |
| coagulation |
| axon |
| protein modification by small protein removal |
| hemostasis |
| multicellular organismal homeostasis |
| phagocytosis |
| anatomical structure homeostasis |
| glutamatergic synapse |
| cytoskeleton |
| axonogenesis |
| regulation of binding |
| cellular response to drug |
| axon development |
| focal adhesion |
| cell morphogenesis involved in neuron differentiation |
| immune response-activating cell surface receptor signaling pathway |
| protein kinase binding |
| wound healing |
| neuron projection morphogenesis |
| immune response-regulating cell surface receptor signaling pathway |
| plasma membrane bounded cell projection morphogenesis |
| cell projection morphogenesis |
| actin cytoskeleton organization |
| regulation of body fluid levels |
| RNA polymerase II proximal promoter sequence-specific DNA binding |
| cell-cell adhesion |
| response to toxic substance |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| cell part morphogenesis |
| regulation of protein serine/threonine kinase activity |
| regulation of cellular protein localization |
| cellular response to organic cyclic compound |
| endocytosis |
| cell morphogenesis involved in differentiation |
| immune response-activating signal transduction |
| regulation of transmembrane transport |
| actin filament-based process |
| response to wounding |
| protein-containing complex |
| immune response-regulating signaling pathway |
| cellular response to organonitrogen compound |
| activation of immune response |
| cellular response to nitrogen compound |
| neuron projection development |
| import into cell |
| chromatin organization |
| enzyme linked receptor protein signaling pathway |
| cell morphogenesis |
| brain development |
| head development |
| regulation of protein kinase activity |
| neuron development |
| cellular component morphogenesis |
| membrane organization |
| positive regulation of immune response |
| regulation of kinase activity |
| regulation of cellular localization |
| response to organic cyclic compound |
| cell adhesion |
| biological adhesion |
| regulation of transferase activity |
| central nervous system development |
| protein modification by small protein conjugation or removal |
| positive regulation of transport |
| response to organonitrogen compound |
| neuron differentiation |
| response to drug |
| regulation of protein localization |
| cellular response to oxygen-containing compound |
| chromosome organization |
| identical protein binding |
| cell activation |
| cell motility |
| localization of cell |
| response to nitrogen compound |
| immune effector process |
| cytoskeleton organization |
| plasma membrane bounded cell projection organization |
| negative regulation of molecular function |
| positive regulation of immune system process |
| regulation of immune response |
| cell projection organization |
| regulation of cell cycle |
| cellular response to endogenous stimulus |
| proteolysis |
| locomotion |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| ATP binding |
| generation of neurons |
| movement of cell or subcellular component |
| response to oxygen-containing compound |
| regulation of phosphorylation |
| extracellular space |
| neurogenesis |
| homeostatic process |
| cell development |
| regulation of immune system process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| establishment of localization in cell |
| regulation of protein modification process |
| regulation of transport |
| vesicle-mediated transport |
| positive regulation of gene expression |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 169/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 8/28 |
| blood | 6/28 |
| bone | 1/25 |
| breast | 12/33 |
| central nervous system | 11/56 |
| cervix | 2/4 |
| colorectal | 4/17 |
| esophagus | 5/13 |
| fibroblast | 0/1 |
| gastric | 4/15 |
| kidney | 5/21 |
| liver | 9/20 |
| lung | 15/75 |
| lymphocyte | 3/14 |
| ovary | 5/26 |
| pancreas | 6/24 |
| peripheral nervous system | 1/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 4/7 |
| thyroid | 1/2 |
| upper aerodigestive | 7/22 |
| urinary tract | 12/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 2193
- Expression level (log2 read counts): 11.22
Expression Distribution
ACTB Expression in NALM6 Cells: 11.22
