ACTR10 [The Human Chemical-Genetic Interaction Map Project]

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======= ACTR10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ACTR10
  * **<color #00a2e8>Official Name</color>**: actin related protein 10
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55860|55860]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NZ32|Q9NZ32]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ACTR10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ACTR10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619731|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Actin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|retrograde axonal transport of mitochondrion|
|dynactin complex|
|axonal transport of mitochondrion|
|retrograde axonal transport|
|mitochondrion transport along microtubule|
|establishment of mitochondrion localization, microtubule-mediated|
|establishment of mitochondrion localization|
|mitochondrion localization|
|axonal transport|
|axon cytoplasm|
|axo-dendritic transport|
|organelle transport along microtubule|
|azurophil granule lumen|
|antigen processing and presentation of exogenous peptide antigen via MHC class II|
|antigen processing and presentation of peptide antigen via MHC class II|
|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|
|ficolin-1-rich granule lumen|
|transport along microtubule|
|cytoskeleton-dependent intracellular transport|
|antigen processing and presentation of exogenous peptide antigen|
|microtubule-based transport|
|antigen processing and presentation of exogenous antigen|
|antigen processing and presentation of peptide antigen|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|antigen processing and presentation|
|microtubule-based movement|
|establishment of organelle localization|
|Golgi vesicle transport|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|organelle localization|
|myeloid leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|microtubule-based process|
|regulated exocytosis|
|leukocyte mediated immunity|
|exocytosis|
|leukocyte activation|
|secretion by cell|
|export from cell|
|cell activation|
|immune effector process|
|secretion|
|intracellular transport|
|movement of cell or subcellular component|
|establishment of localization in cell|
|immune response|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-2.49|
|[[:results:exp481|Ethambutol 25μM R08 exp481]]|-1.92|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-1.91|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:ggnbp2|GGNBP2]]|0.446|
|[[:human genes:r:rnmt|RNMT]]|0.443|
|[[:human genes:d:dpagt1|DPAGT1]]|0.438|
|[[:human genes:t:tbca|TBCA]]|0.433|
|[[:human genes:t:tti2|TTI2]]|0.427|
|[[:human genes:n:nae1|NAE1]]|0.417|
|[[:human genes:g:gmppb|GMPPB]]|0.414|
|[[:human genes:r:rtcb|RTCB]]|0.414|
|[[:human genes:p:pelo|PELO]]|0.413|
|[[:human genes:m:med16|MED16]]|0.41|
|[[:human genes:y:yars|YARS]]|0.408|
|[[:human genes:t:thg1l|THG1L]]|0.408|
|[[:human genes:t:tp53rk|TP53RK]]|0.406|
|[[:human genes:a:alg2|ALG2]]|0.406|
|[[:human genes:t:telo2|TELO2]]|0.404|
|[[:human genes:d:dad1|DAD1]]|0.403|
|[[:human genes:e:eprs|EPRS]]|0.403|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.402|
|[[:human genes:f:fgfr1op|FGFR1OP]]|0.401|
|[[:human genes:g:gnb1l|GNB1L]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 225/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|8/28|
|blood|10/28|
|bone|13/26|
|breast|8/33|
|central nervous system|24/56|
|cervix|2/4|
|colorectal|2/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|4/16|
|kidney|12/21|
|liver|7/20|
|lung|16/75|
|lymphocyte|4/16|
|ovary|6/26|
|pancreas|4/24|
|peripheral nervous system|9/16|
|plasma cell|2/15|
|prostate|1/1|
|skin|6/24|
|soft tissue|2/9|
|thyroid|1/2|
|upper aerodigestive|8/22|
|urinary tract|11/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 985
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ACTR10 Expression in NALM6 Cells: 5.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>