ACTR1A [The Human Chemical-Genetic Interaction Map Project]

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======= ACTR1A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ACTR1A
  * **<color #00a2e8>Official Name</color>**: actin related protein 1A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10121|10121]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P61163|P61163]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ACTR1A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ACTR1A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605143|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 8-13 copies per dynactin molecule, and is the most abundant molecule in the dynactin complex. It is an actin-related protein, and is approximately 60% identical at the amino acid level to conventional actin. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Actin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|microtubule cortical anchor activity|
|nuclear migration along microtubule|
|dynactin complex|
|COPI-coated vesicle|
|manchette|
|cell cortex region|
|nuclear migration|
|nucleus localization|
|establishment of mitotic spindle orientation|
|microtubule associated complex|
|establishment of mitotic spindle localization|
|establishment of spindle orientation|
|establishment of spindle localization|
|spindle localization|
|organelle transport along microtubule|
|ciliary basal body-plasma membrane docking|
|antigen processing and presentation of exogenous peptide antigen via MHC class II|
|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|
|antigen processing and presentation of peptide antigen via MHC class II|
|microtubule cytoskeleton organization involved in mitosis|
|establishment of cell polarity|
|G2/M transition of mitotic cell cycle|
|cell cycle G2/M phase transition|
|centriole|
|microtubule cytoskeleton|
|transport along microtubule|
|organelle localization by membrane tethering|
|cytoskeleton-dependent intracellular transport|
|antigen processing and presentation of exogenous peptide antigen|
|membrane docking|
|microtubule-based transport|
|antigen processing and presentation of exogenous antigen|
|antigen processing and presentation of peptide antigen|
|regulation of G2/M transition of mitotic cell cycle|
|establishment or maintenance of cell polarity|
|regulation of cell cycle G2/M phase transition|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|antigen processing and presentation|
|mitotic cell cycle phase transition|
|microtubule-based movement|
|cell cycle phase transition|
|cilium assembly|
|establishment of organelle localization|
|cilium organization|
|Golgi vesicle transport|
|regulation of mitotic cell cycle phase transition|
|plasma membrane bounded cell projection assembly|
|regulation of cell cycle phase transition|
|cell projection assembly|
|microtubule cytoskeleton organization|
|centrosome|
|spermatogenesis|
|male gamete generation|
|organelle localization|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|microtubule-based process|
|mitotic cell cycle|
|gamete generation|
|regulation of cell cycle process|
|organelle assembly|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|multi-organism reproductive process|
|cell cycle process|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|regulation of cell cycle|
|cell cycle|
|reproductive process|
|reproduction|
|ATP binding|
|intracellular transport|
|movement of cell or subcellular component|
|establishment of localization in cell|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-4.25|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-3.36|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|-2.77|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-2.18|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|-1.71|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|1.78|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.23|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:v:vezt|VEZT]]|0.441|
|[[:human genes:s:ska1|SKA1]]|0.418|
|[[:human genes:k:kif18a|KIF18A]]|0.408|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 353/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|11/28|
|blood|12/28|
|bone|13/26|
|breast|18/33|
|central nervous system|32/56|
|cervix|0/4|
|colorectal|4/17|
|esophagus|10/13|
|fibroblast|1/1|
|gastric|6/16|
|kidney|11/21|
|liver|8/20|
|lung|35/75|
|lymphocyte|7/16|
|ovary|12/26|
|pancreas|13/24|
|peripheral nervous system|11/16|
|plasma cell|3/15|
|prostate|0/1|
|skin|15/24|
|soft tissue|4/9|
|thyroid|1/2|
|upper aerodigestive|16/22|
|urinary tract|16/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3503
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.23 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ACTR1A Expression in NALM6 Cells: 6.23'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>