ACTR1A

Gene Information

Official Symbol: ACTR1A
Official Name: actin related protein 1A
Aliases and Previous Symbols: N/A
Entrez ID: 10121
UniProt: P61163
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 8-13 copies per dynactin molecule, and is the most abundant molecule in the dynactin complex. It is an actin-related protein, and is approximately 60% identical at the amino acid level to conventional actin. [provided by RefSeq, Jul 2008].
UniProt Summary: Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
BI-6727 0.0125μM R03 exp97	-4.25
BI-2536 0.0042μM R03 exp95	-3.36
GSK461364A 0.005μM R03 exp125	-2.77
GSK626616 14μM R08 exp485	-2.18
GSK591 2.6μM R03 exp128	-1.71
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	1.78
UM131593 0.2μM R03 exp106	2.23

Global Fraction of Cell Lines Where Essential: 353/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	11/28
blood	12/28
bone	13/26
breast	18/33
central nervous system	32/56
cervix	0/4
colorectal	4/17
esophagus	10/13
fibroblast	1/1
gastric	6/16
kidney	11/21
liver	8/20
lung	35/75
lymphocyte	7/16
ovary	12/26
pancreas	13/24
peripheral nervous system	11/16
plasma cell	3/15
prostate	0/1
skin	15/24
soft tissue	4/9
thyroid	1/2
upper aerodigestive	16/22
urinary tract	16/29
uterus	4/5

Essentiality in NALM6

Essentiality Rank: 3503
Expression level (log2 read counts): 6.23

Expression Distribution

Gene	Correlation
VEZT	0.441
SKA1	0.418
KIF18A	0.408

microtubule cortical anchor activity
nuclear migration along microtubule
dynactin complex
COPI-coated vesicle
manchette
cell cortex region
nuclear migration
nucleus localization
establishment of mitotic spindle orientation
microtubule associated complex
establishment of mitotic spindle localization
establishment of spindle orientation
establishment of spindle localization
spindle localization
organelle transport along microtubule
ciliary basal body-plasma membrane docking
antigen processing and presentation of exogenous peptide antigen via MHC class II
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
antigen processing and presentation of peptide antigen via MHC class II
microtubule cytoskeleton organization involved in mitosis
establishment of cell polarity
G2/M transition of mitotic cell cycle
cell cycle G2/M phase transition
centriole
microtubule cytoskeleton
transport along microtubule
organelle localization by membrane tethering
cytoskeleton-dependent intracellular transport
antigen processing and presentation of exogenous peptide antigen
membrane docking
microtubule-based transport
antigen processing and presentation of exogenous antigen
antigen processing and presentation of peptide antigen
regulation of G2/M transition of mitotic cell cycle
establishment or maintenance of cell polarity
regulation of cell cycle G2/M phase transition
endoplasmic reticulum to Golgi vesicle-mediated transport
antigen processing and presentation
mitotic cell cycle phase transition
microtubule-based movement