ACTR2 [The Human Chemical-Genetic Interaction Map Project]

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======= ACTR2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ACTR2
  * **<color #00a2e8>Official Name</color>**: actin related protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10097|10097]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P61160|P61160]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ACTR2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ACTR2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604221|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. {ECO:0000269|PubMed:9000076}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Actin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|podosome core|
|meiotic chromosome movement towards spindle pole|
|cellular response to trichostatin A|
|response to trichostatin A|
|actin cap|
|meiotic cytokinesis|
|chromosome movement towards spindle pole|
|positive regulation of double-strand break repair via homologous recombination|
|invadopodium|
|Arp2/3 protein complex|
|asymmetric cell division|
|actin cortical patch|
|positive regulation of dendritic spine morphogenesis|
|Arp2/3 complex-mediated actin nucleation|
|regulation of double-strand break repair via nonhomologous end joining|
|response to immobilization stress|
|positive regulation of double-strand break repair|
|actin nucleation|
|positive regulation of dendrite morphogenesis|
|positive regulation of DNA recombination|
|positive regulation of dendritic spine development|
|regulation of dendritic spine morphogenesis|
|regulation of double-strand break repair via homologous recombination|
|spindle localization|
|site of double-strand break|
|positive regulation of DNA repair|
|establishment of chromosome localization|
|positive regulation of dendrite development|
|regulation of dendritic spine development|
|chromosome localization|
|regulation of double-strand break repair|
|associative learning|
|ephrin receptor signaling pathway|
|meiotic chromosome segregation|
|azurophil granule lumen|
|regulation of dendrite morphogenesis|
|positive regulation of actin filament polymerization|
|cytoskeleton-dependent cytokinesis|
|regulation of postsynapse organization|
|positive regulation of response to DNA damage stimulus|
|cytokinesis|
|structural constituent of cytoskeleton|
|regulation of DNA recombination|
|cellular response to antibiotic|
|regulation of DNA repair|
|ficolin-1-rich granule lumen|
|response to ethanol|
|positive regulation of protein polymerization|
|Fc-gamma receptor signaling pathway involved in phagocytosis|
|immune response-regulating cell surface receptor signaling pathway involved in phagocytosis|
|Fc receptor mediated stimulatory signaling pathway|
|Fc-gamma receptor signaling pathway|
|cytosolic transport|
|learning|
|regulation of dendrite development|
|meiotic nuclear division|
|positive regulation of cell morphogenesis involved in differentiation|
|cellular response to interferon-gamma|
|regulation of actin filament polymerization|
|meiotic cell cycle process|
|lamellipodium|
|response to interferon-gamma|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|positive regulation of DNA metabolic process|
|establishment or maintenance of cell polarity|
|positive regulation of supramolecular fiber organization|
|actin filament binding|
|actin cytoskeleton|
|regulation of synapse organization|
|regulation of response to DNA damage stimulus|
|nuclear chromosome segregation|
|positive regulation of cytoskeleton organization|
|regulation of protein polymerization|
|meiotic cell cycle|
|regulation of synapse structure or activity|
|response to alcohol|
|actin filament organization|
|Fc receptor signaling pathway|
|positive regulation of protein complex assembly|
|postsynaptic density|
|learning or memory|
|regulation of actin filament organization|
|microtubule-based movement|
|chromosome segregation|
|positive regulation of neuron projection development|
|nuclear division|
|cognition|
|response to antibiotic|
|regulation of cell morphogenesis involved in differentiation|
|organelle fission|
|phagocytosis|
|regulation of actin cytoskeleton organization|
|cilium assembly|
|regulation of supramolecular fiber organization|
|regulation of DNA metabolic process|
|establishment of organelle localization|
|cilium organization|
|positive regulation of neuron differentiation|
|regulation of cellular component size|
|positive regulation of cell projection organization|
|regulation of actin filament-based process|
|focal adhesion|
|plasma membrane bounded cell projection assembly|
|immune response-activating cell surface receptor signaling pathway|
|regulation of protein complex assembly|
|supramolecular fiber organization|
|cell projection assembly|
|positive regulation of neurogenesis|
|immune response-regulating cell surface receptor signaling pathway|
|neutrophil degranulation|
|regulation of cell morphogenesis|
|neutrophil activation involved in immune response|
|cell division|
|actin cytoskeleton organization|
|regulation of neuron projection development|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|response to toxic substance|
|leukocyte degranulation|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of anatomical structure size|
|myeloid leukocyte mediated immunity|
|positive regulation of cellular component biogenesis|
|myeloid cell activation involved in immune response|
|positive regulation of nervous system development|
|regulation of cytoskeleton organization|
|cellular response to organic cyclic compound|
|positive regulation of cell development|
|immune response-activating signal transduction|
|actin filament-based process|
|behavior|
|organelle localization|
|myeloid leukocyte activation|
|immune response-regulating signaling pathway|
|cellular response to organonitrogen compound|
|positive regulation of organelle organization|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|activation of immune response|
|regulation of neuron differentiation|
|cellular response to nitrogen compound|
|microtubule-based process|
|regulation of plasma membrane bounded cell projection organization|
|regulated exocytosis|
|regulation of cell projection organization|
|enzyme linked receptor protein signaling pathway|
|regulation of cellular response to stress|
|organelle assembly|
|innate immune response|
|leukocyte mediated immunity|
|exocytosis|
|regulation of neurogenesis|
|membrane organization|
|positive regulation of immune response|
|response to organic cyclic compound|
|regulation of nervous system development|
|leukocyte activation|
|regulation of cell development|
|defense response to other organism|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|cell cycle process|
|response to organonitrogen compound|
|secretion by cell|
|cellular response to cytokine stimulus|
|response to drug|
|export from cell|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|cell activation|
|response to nitrogen compound|
|immune effector process|
|response to cytokine|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|secretion|
|regulation of immune response|
|positive regulation of immune system process|
|cell projection organization|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|cell cycle|
|defense response|
|positive regulation of developmental process|
|nervous system process|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|regulation of response to stress|
|ATP binding|
|intracellular transport|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|establishment of localization in cell|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|vesicle-mediated transport|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-2.64|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-2.29|
|[[:results:exp169|BH1 1μM R04 exp169]]|-2.14|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-2.02|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-1.99|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|-1.87|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|-1.82|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|-1.78|
|[[:results:exp130|JQ1 0.01μM R03 exp130]]|-1.75|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|-1.73|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|2.08|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:arpc4|ARPC4]]|0.724|
|[[:human genes:a:arpc2|ARPC2]]|0.602|
|[[:human genes:a:actr3|ACTR3]]|0.529|
|[[:human genes:v:vps29|VPS29]]|0.496|
|[[:human genes:c:commd5|COMMD5]]|0.491|
|[[:human genes:c:commd3|COMMD3]]|0.49|
|[[:human genes:c:commd7|COMMD7]]|0.485|
|[[:human genes:c:commd9|COMMD9]]|0.469|
|[[:human genes:v:vkorc1l1|VKORC1L1]]|0.463|
|[[:human genes:c:chka|CHKA]]|0.459|
|[[:human genes:c:ccdc22|CCDC22]]|0.455|
|[[:human genes:c:commd4|COMMD4]]|0.447|
|[[:human genes:n:nckap1l|NCKAP1L]]|0.44|
|[[:human genes:c:commd10|COMMD10]]|0.432|
|[[:human genes:c:ccdc53|CCDC53]]|0.421|
|[[:human genes:a:acsl4|ACSL4]]|0.412|
|[[:human genes:r:ralgapb|RALGAPB]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 611/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|25/28|
|blood|22/28|
|bone|17/26|
|breast|24/33|
|central nervous system|43/56|
|cervix|2/4|
|colorectal|14/17|
|esophagus|10/13|
|fibroblast|1/1|
|gastric|13/16|
|kidney|17/21|
|liver|19/20|
|lung|59/75|
|lymphocyte|15/16|
|ovary|24/26|
|pancreas|21/24|
|peripheral nervous system|12/16|
|plasma cell|12/15|
|prostate|1/1|
|skin|19/24|
|soft tissue|6/9|
|thyroid|2/2|
|upper aerodigestive|19/22|
|urinary tract|26/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2206
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.51 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ACTR2 Expression in NALM6 Cells: 8.51'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>