ACTR5 [The Human Chemical-Genetic Interaction Map Project]

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======= ACTR5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ACTR5
  * **<color #00a2e8>Official Name</color>**: actin related protein 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79913|79913]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H9F9|Q9H9F9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ACTR5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ACTR5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619730|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Involved in DNA double-strand break repair and UV-damage excision repair. {ECO:0000269|PubMed:19014934, ECO:0000269|PubMed:20855601}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Actin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|UV-damage excision repair|
|Ino80 complex|
|3-5 DNA helicase activity|
|ATP-dependent chromatin remodeling|
|cellular response to UV|
|DNA duplex unwinding|
|cellular response to light stimulus|
|DNA geometric change|
|response to UV|
|chromatin remodeling|
|cellular response to radiation|
|double-strand break repair|
|DNA recombination|
|protein deubiquitination|
|DNA conformation change|
|protein modification by small protein removal|
|response to light stimulus|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|response to radiation|
|DNA repair|
|chromatin organization|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|protein modification by small protein conjugation or removal|
|chromosome organization|
|response to abiotic stimulus|
|proteolysis|
|cellular response to stress|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-2.18|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-1.78|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|1.72|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|1.73|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|1.75|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|1.79|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|1.82|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|1.87|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|1.9|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|1.9|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|1.91|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|2.1|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|2.2|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|2.23|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|2.23|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|2.39|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|2.53|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|2.71|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|2.81|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|3.19|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:i:ino80c|INO80C]]|0.624|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.587|
|[[:human genes:u:uchl5|UCHL5]]|0.553|
|[[:human genes:n:nfrkb|NFRKB]]|0.513|
|[[:human genes:i:ino80|INO80]]|0.513|
|[[:human genes:i:ino80b|INO80B]]|0.443|
|[[:human genes:p:pih1d1|PIH1D1]]|0.429|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 10/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|1/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|1/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/7|
|thyroid|1/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1666
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ACTR5 Expression in NALM6 Cells: 4.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>