ACTR5

Entrez Summary: N/A
UniProt Summary: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Involved in DNA double-strand break repair and UV-damage excision repair. {ECO:0000269|PubMed:19014934, ECO:0000269|PubMed:20855601}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Diepoxybutane 3μM R07 exp354	-2.18
Aphidicolin 0.4μM R08 exp440	-1.78
QNZ 0.01μM R08 exp439	1.72
CB-5083 0.4μM R08 exp468	1.73
MLN-4924 0.2μM R00 exp21	1.75
VER-155008 3.9μM R06 exp301	1.79
Golgicide-A 4μM R03 exp122	1.82
RO-3307 4.7μM R02 exp80	1.87
Dimethyl-Sulfoxide 1pc R03 exp120	1.9
LY2090314 0.003μM R08 exp500 no dilution day6	1.9
THZ531 0.225μM R08 exp444	1.91
Ethanol 0.01 R05 exp234	2.1
Latrunculin-B 10μM R07 exp374	2.2
I-BRD9 4μM R07 exp365	2.23
Rotenone 0.07μM R08 exp431	2.23
Bortezomib 0.005μM R00 exp6	2.39
ML-792 0.2μM R08 exp505	2.53
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	2.71
Cerivastatin 0.15μM R05 exp226	2.81
Fluvastatin 2.2μM R06 exp282	3.19

Global Fraction of Cell Lines Where Essential: 10/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	1/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	1/20
lung	0/75
lymphocyte	0/14
ovary	1/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/7
thyroid	1/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

UV-damage excision repair
Ino80 complex
3-5 DNA helicase activity
ATP-dependent chromatin remodeling
cellular response to UV
DNA duplex unwinding
cellular response to light stimulus
DNA geometric change
response to UV
chromatin remodeling
cellular response to radiation
double-strand break repair
DNA recombination
protein deubiquitination
DNA conformation change
protein modification by small protein removal
response to light stimulus
cellular response to abiotic stimulus
cellular response to environmental stimulus
response to radiation
DNA repair
chromatin organization
DNA metabolic process
cellular response to DNA damage stimulus
protein modification by small protein conjugation or removal
chromosome organization
response to abiotic stimulus
proteolysis
cellular response to stress