ACTR8 [The Human Chemical-Genetic Interaction Map Project]

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======= ACTR8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ACTR8
  * **<color #00a2e8>Official Name</color>**: actin related protein 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=93973|93973]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H981|Q9H981]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ACTR8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ACTR8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619716|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Actin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Ino80 complex|
|3-5 DNA helicase activity|
|ATP-dependent chromatin remodeling|
|DNA duplex unwinding|
|DNA geometric change|
|chromatin remodeling|
|double-strand break repair|
|DNA recombination|
|protein deubiquitination|
|protein modification by small protein removal|
|DNA conformation change|
|centrosome|
|cell division|
|DNA repair|
|chromatin organization|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|protein modification by small protein conjugation or removal|
|chromosome organization|
|proteolysis|
|cell cycle|
|ATP binding|
|cellular response to stress|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|-1.86|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-1.86|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|-1.76|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|-1.75|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 413/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|17/28|
|blood|17/28|
|bone|11/25|
|breast|16/33|
|central nervous system|26/56|
|cervix|4/4|
|colorectal|10/17|
|esophagus|9/13|
|fibroblast|0/1|
|gastric|8/15|
|kidney|14/21|
|liver|11/20|
|lung|43/75|
|lymphocyte|7/14|
|ovary|16/26|
|pancreas|16/24|
|peripheral nervous system|11/16|
|plasma cell|10/15|
|prostate|1/1|
|skin|14/24|
|soft tissue|5/7|
|thyroid|1/2|
|upper aerodigestive|12/22|
|urinary tract|17/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 152
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.79 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ACTR8 Expression in NALM6 Cells: 5.79'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>